High seroprevalence of Borrelia miyamotoi antibodies in forestry workers and individuals suspected of human granulocytic anaplasmosis in the Netherlands.
High seroprevalence of Borrelia miyamotoi antibodies in forestry workers and individuals suspected of human granulocytic anaplasmosis in the Netherlands.
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DOI：
10.1002/nmi2.59
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发表时间：
2014-09
影响因子：
4
通讯作者：
Sprong, H
中科院分区：
文献类型：
--
作者：
Jahfari, S;Herremans, T;Platonov, A E;Kuiper, H;Karan, L S;Vasilieva, O;Koopmans, M P G;Hovius, J W R;Sprong, H
荷兰的大量接触宫本疏螺旋体是通过被蓖麻硬蜱叮咬而发生的，这种蜱也传播伯氏疏螺旋体和嗜吞噬细胞无形体。欧洲人群中宫本双歧杆菌感染的直接证据很少。一种伴有高烧的类似流感的疾病，类似于人类粒细胞无形体病，被归因于相对较小群体的宫本伯克氏菌感染。病例报告中也描述了与慢性脑膜脑炎相关的宫本疏螺旋体感染。假设针对宫本博拉特氏菌抗原的 IgG 抗体反应反映了（经受的）感染，则检查了不同风险组中的血清阳性率。来自俄罗斯的十分之九的已确诊的宫本博拉特氏菌感染的血清被发现对所使用的重组抗原呈阳性，并且在二期梅毒患者中没有观察到显着的交叉反应。献血者的血清阳性率为 2.0%（95% CI 0.4-5.7%）。经血清学确诊的莱姆神经疏螺旋体病患者的血清阳性率升高为 7.4% (2.0–17.9%)，或未确诊的莱姆神经疏螺旋体病患者的血清阳性率升高为 8.6% (1.8–23%)，与献血者的血清阳性率没有显着差异。抗 B 抗体的流行。 林业工人中宫本抗体的比例为 10%（5.3-16.8%），血清学未确诊但疑似人粒细胞无形体病的患者中宫本抗体的比例为 14.6%（9.0-21.8%）；与献血者的血清流行率相比，这些数字明显更高。我们的研究结果表明，宫本疏螺旋体感染发生在荷兰接触蜱虫的个体中。此外，在荷兰和其他蓖麻蜱流行的国家，对于报告有蜱虫叮咬和病因未明的发热性疾病的患者，应考虑宫本伯克氏菌感染。
Substantial exposure to Borrelia miyamotoi occurs through bites from Ixodes ricinus ticks in the Netherlands, which also transmit Borrelia burgdorferi sensu lato and Anaplasma phagocytophilum. Direct evidence for B. miyamotoi infection in European populations is scarce. A flu-like illness with high fever, resembling human granulocytic anaplasmosis, has been attributed to B. miyamotoi infections in relatively small groups. Borrelia miyamotoi infections associated with chronic meningoencephalitis have also been described in case reports. Assuming that an IgG antibody response against B. miyamotoi antigens reflects (endured) infection, the seroprevalence in different risk groups was examined. Sera from nine out of ten confirmed B. miyamotoi infections from Russia were found to be positive with the recombinant antigen used, and no significant cross-reactivity was observed in secondary syphilis patients. The seroprevalence in blood donors was set at 2.0% (95% CI 0.4–5.7%). Elevated seroprevalences in individuals with serologically confirmed, 7.4% (2.0–17.9%), or unconfirmed, 8.6% (1.8–23%), Lyme neuroborreliosis were not significantly different from those in blood donors. The prevalence of anti-B. miyamotoi antibodies among forestry workers was 10% (5.3–16.8%) and in patients with serologically unconfirmed but suspected human granulocytic anaplasmosis was 14.6% (9.0–21.8%); these were significantly higher compared with the seroprevalence in blood donors. Our findings indicate that infections with B. miyamotoi occur in tick-exposed individuals in the Netherlands. In addition, B. miyamotoi infections should be considered in patients reporting tick bites and febrile illness with unresolved aetiology in the Netherlands, and other countries where I. ricinus ticks are endemic.