Effect of pH on in vitro antimicrobial susceptibility of the Bacteroides fragilis group
Effect of pH on in vitro antimicrobial susceptibility of the Bacteroides fragilis group
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DOI：
10.1128/aac.41.9.2047
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发表时间：
1997-09-01
影响因子：
4.9
通讯作者：
Snydman, DR
中科院分区：
文献类型：
--
作者：
Falagas, ME;McDermott, L;Snydman, DR
本文研究了pH（7.1、6.3和5.8）对59株脆弱类杆菌和60株其它B类杆菌体外亲和性的影响。fragilis组的种类为曲伐沙星、环丙沙星、克林霉素、氨苄西林-舒巴坦、哌拉西林-他唑巴坦、亚胺培南和美罗培南。对于检测的每种药物，几何平均MIC在pH 5.8时最高，在pH 6.3时居中，在pH 7.1时最低。不同抗生素的pH值效应的大小差异很大。这些数据表明酸性pH降低了B的体外亲和性。fragilis组对几种抗生素敏感。
We studied the effect of pH (7.1, 6.3, and 5.8) on the in vitro susceptibilities of 59 isolates of Bacteroides fragilis and 60 isolates of other B. fragilis group species to trovafloxacin, ciprofloxacin, clindamycin, ampicillin-sulbactam, piperacillin-tazobactam, imipenem, and meropenem. For each agent tested the geometric mean MIC was highest at pH 5.8, intermediate at pH 6.3, and lowest at pH 7.1. The magnitude of the pH effect varied greatly among different antibiotics. These data show that an acidic pH decreases the in vitro susceptibilities of the B. fragilis group to several antibiotics.