Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
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DOI：
10.1016/s0092-8674(00)80405-5
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发表时间：
1997-10-17
期刊：
影响因子：
64.5
通讯作者：
Greenberg, ME
中科院分区：
文献类型：
--
作者：
Datta, SR;Dudek, H;Greenberg, ME
Growth factors can promote cell survival by activating the phosphatidylinositide-3'-OH kinase and its downstream target, the serine-threonine kinase Akt. However, the mechanism by which Akt functions to promote survival is not understood. We show that growth factor activation of the PI3'K/Akt signaling pathway culminates in the phosphorylation of the BCL-2 family member BAD, thereby suppressing apoptosis and promoting cell survival. Akt phosphorylates BAD in vitro and in vivo, and blocks the BAD-induced death of primary neurons in a site-specific manner. These findings define a mechanism by which growth factors directly inactivate a critical component of the cell-intrinsic death machinery.
