APOLIPOPROTEIN-E AND APOLIPOPROTEIN-B POLYMORPHISMS - LONGEVITY FACTORS ASSESSED IN NONAGENARIANS
APOLIPOPROTEIN-E AND APOLIPOPROTEIN-B POLYMORPHISMS - LONGEVITY FACTORS ASSESSED IN NONAGENARIANS
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DOI：
10.1016/0021-9150(94)90011-6
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发表时间：
1994-01-01
期刊：
影响因子：
5.3
通讯作者：
KESANIEMI, YA
中科院分区：
文献类型：
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作者：
KERVINEN, K;SAVOLAINEN, MJ;KESANIEMI, YA
为检测冠心病(CHD)的遗传危险因素在超高龄人群中的患病率是否较低，我们调查了非老年人群和青年对照组载脂蛋白E(APE)和载脂蛋白B(APE B)的等位基因频率和血浆脂蛋白(A)水平。Apo E基因epsilon 4等位基因频率在非老年组明显低于中青年组(P<；0.05)。载脂蛋白B的EcoRI等位基因R-频率在非老年组较低，而载脂蛋白B的XbaI多态和血浆脂蛋白(A)浓度的等位基因频率在非老年组和青年组之间无差异。这些发现有力地表明，这些潜在的遗传危险因素的存在，即载脂蛋白E的epsilon 4等位基因和载脂蛋白B的R等位基因，降低了个体达到极高年龄的可能性。
To test if the prevalence of genetic risk factors for coronary heart disease (CHD) is low in individuals who have reached an extremely old age, the allele frequencies of apolipoprotein E (ape E) and B (ape B) polymorphisms and plasma lipoprotein(a) levels were investigated in nonagenarians and in younger control groups. The frequency of the epsilon 4 allele of apo E was significantly lower in the nonagenarians than in the middle-aged and young adults (P < 0.05). Also, the frequency of EcoRI allele R- of apo B was low in the nonagenarians, whereas the allele frequency for the XbaI polymorphism of apo B and plasma lipoprotein(a) concentrations did not differ between the nonagenarians and the younger groups. These findings strongly suggest that the presence of these potential genetic risk factors for CHD, namely the epsilon 4 allele of apo E and the R- allele of apo B, decreases the probability of an individual reaching an extremely old age.