HIGH-DOSE INTRAVENOUS GAMMAGLOBULIN FOR IDIOPATHIC THROMBOCYTOPENIC PURPURA IN CHILDHOOD
HIGH-DOSE INTRAVENOUS GAMMAGLOBULIN FOR IDIOPATHIC THROMBOCYTOPENIC PURPURA IN CHILDHOOD
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DOI：
10.1016/s0140-6736(81)92400-4
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发表时间：
1981-06
期刊：
影响因子：
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通讯作者：
P. Imbach;V. D'apuzzo;A. Hirt;E. Rossi;M. Vest;S. Barandun;C. Baumgartner;A. Morell;M. Schöni;H. Wagner
中科院分区：
文献类型：
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作者：
P. Imbach;V. D'apuzzo;A. Hirt;E. Rossi;M. Vest;S. Barandun;C. Baumgartner;A. Morell;M. Schöni;H. Wagner
七名患有慢性或间歇性的儿童和六名患有急性特发性血小板减少性紫癜（ITP）的儿童接受了大剂量静脉注射多价完整免疫球蛋白（Ig）的治疗。所有患者的血小板计数在 5 天内急剧上升，但最初的反应和随后的病程因患者而异。在患有慢性 ITP 的儿童中，脾切除患者的初始反应比非脾切除患者更明显。在急性 ITP 患者中，两名仍保持 Ig 依赖性的患者的初始反应比四名不需要维持治疗的患者要小。在 90 - 110 天的观察期间，六名慢性 ITP 患者中的五名可以单独使用 Ig 维持治疗。没有观察到 Ig 治疗的不良反应。
Seven children with chronic or intermittent and six with acute idiopathic thrombocytopenic purpura (ITP) were treated with large intravenous doses of polyvalent, intact immunoglobulin (Ig). In all patients the platelet count rose sharply within 5 days, but the initial response and the subsequent course varied from patient to patient. Among children with chronic ITP the initial response was more marked in splenectomised than in non-splenectomised patients. Among those with acute ITP the two who remained Ig dependent had a smaller initial response than the four patients who required no maintenance treatment. During the 90 - 110 days of observation five of six patients with chronic ITP could be maintained with Ig alone. No untoward effects of Ig therapy were observed.