Comparison of efficacy and safety of atorvastatin (10 mg) with simvastatin (10 mg) at six weeks
Comparison of efficacy and safety of atorvastatin (10 mg) with simvastatin (10 mg) at six weeks
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DOI：
10.1016/s0002-9149(00)01430-2
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发表时间：
2001-03-01
影响因子：
2.8
通讯作者：
Zieve, F
中科院分区：
文献类型：
--
作者：
Insull, W;Kafonek, S;Zieve, F
在一项为期54周、开放标签、多中心、平行组、达标治疗研究中，确定了阿托伐他汀与辛伐他汀相比的6周疗效和安全性。共有1，424例混合性血脂异常（甘油三酯200 - 600 mg/dl [2.26 - 6.77 mmol/L]）患者被分层至2组之一（糖尿病或非糖尿病）。然后患者随机接受阿托伐他汀10 mg/天（n = 730）或辛伐他汀10 mg/天（n = 694），通过测量血脂参数（包括低密度脂蛋白（LDL）胆固醇、总胆固醇、甘油三酯和载脂蛋白B）较基线的变化来确定疗效。与辛伐他汀相比，阿托伐他汀产生显著增加（p
The 6-week efficacy and safety of atorvastatin versus simvastatin was determined during a 54-week, openlabel, multicenter, parallel-arm, treat-to-target study. In all, 1,424 patients with mixed dyslipidemia (triglyceride 200 to 600 mg/dl [2.26 to 6.77 mmol/L]) were stratified to 1 of 2 groups (diabetes or no diabetes). Patients were then randomized to receive either atorvastatin 10 mg/ day (n = 730) or simvastatin 10 mg/day (n = 694), Efficacy was determined by measuring changes from baseline in lipid parameters including low-density lipoprotein (LDL) cholesterol, total cholesterol, triglycerides, and apolipoprotein B. Compared with simvastatin, atorvastatin produced significantly greater (p