Effects of naringin on the proliferation and osteogenic differentiation of human bone mesenchymal stem cell
Effects of naringin on the proliferation and osteogenic differentiation of human bone mesenchymal stem cell
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DOI：
10.1016/j.ejphar.2009.01.035
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发表时间：
2009-04-01
影响因子：
5
通讯作者：
Xu, Zhan-wang
中科院分区：
文献类型：
--
作者：
Peng-Zhang;Dai, Ke-rong;Xu, Zhan-wang
中药骨碎补是治疗骨质疏松症和骨不连的常用中药。现代药理学研究表明，柚皮苷是骨碎补的主要有效成分，能诱导成骨细胞系中成骨标志物的表达。然而，以前的研究还没有描述其对骨髓间充质干细胞（BMSCs）的影响。本实验将人骨髓基质细胞与不同浓度的柚皮苷溶液共培养，分析其成骨分化指标和增殖能力。结果表明，一定浓度（1-100 μ g/ml）的柚皮苷溶液可促进人BMSCs的增殖和成骨分化。本研究也很好地解释了骨碎补抗骨质疏松和治疗骨不连的作用机理，为从中药中寻找成骨分化剂做出了贡献。(C)2009爱思唯尔有限公司版权所有。
Rhizoma drynariae is used commonly in the treatment of osteoporosis and bone nonunion in traditional Chinese medicine. Modern pharmacological research indicates that naringin is the main effective component of rhizoma drynariae, which can induce the expression of the osteogenic marker in the osteoblast cell line. However, no former study has described its effect on bone mesenchymal stem cells (BMSCs). In our experiment, we co-cultured human BMSCs with different concentrations of naringin solution, then the osteogenic differentiation markers and proliferation ability were analyzed. The results indicated that a certain concentration (1-100 mu g/ml) of the naringin solution may enhance the proliferation and osteogenic differentiation of human BMSCs. Also, our research explains excellently the anti-osteoporotic and bone nonunion treatment mechanism of rhizoma drynariae, thus contributing to the exploration of osteogenic differentiation agents from Chinese herbs. (C) 2009 Elsevier B.V. All rights reserved.