INTERLEUKIN-8 STIMULATES ANGIOGENESIS IN RATS
INTERLEUKIN-8 STIMULATES ANGIOGENESIS IN RATS
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DOI：
10.1007/bf00916100
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发表时间：
1993-04-01
期刊：
影响因子：
5.1
通讯作者：
FAN, TPD
中科院分区：
文献类型：
--
作者：
HU, DE;HORI, Y;FAN, TPD
为了验证细胞因子白介素-6 （IL-6）和IL-8可能在慢性炎症性疾病的异常新生血管中发挥调节作用的假设，我们在大鼠海绵模型中检测了它们的作用，并将它们与IL-1和肿瘤坏死因子- α (tnf - α)的作用进行了比较。每日剂量3 pmol IL-8、IL-1、tnf - α，而非IL-6，显著加速海绵诱导的血管生成。尽管较低剂量（0.3 pmol）的这些细胞因子无活性，但IL-1与阈下每日剂量（10 pmol）的P物质（SP）和缓激素（BK）协同作用，产生强烈的血管生成反应。相比之下，IL-8只与IL-1有积极的相互作用，而与tnf - α、SP或BK没有积极的相互作用，IL-6与SP之间没有协同作用或拮抗作用。这些结果表明，慢性炎症中血管生成因子和细胞因子之间存在离散的相互作用，海绵模型是研究这种相互作用的良好手段。
To test the hypothesis that the cytokines interleukin-6 (IL-6) and IL-8 may play regulatory roles in the aberrant neovascularization in chronic inflammatory diseases, we examined their effects in a rat sponge model and compared their actions with those of IL-1 and tumor necrosis factor-alpha (TNF-alpha). Daily doses of 3 pmol IL-8, IL-1, TNF-alpha, but not IL-6, significantly accelerated the sponge-induced angiogenesis. Although lower doses (0.3 pmol) of these cytokines were inactive, IL-1 acted synergistically with subthreshold daily doses (10 pmol) of substance P (SP) and bradykinin (BK) to produce an intense angiogenic response. In contrast, IL-8 only interacted positively with IL-1, but not TNF-alpha, SP, or BK. There was no synergism or antagonism between IL-6 and SP. These results demonstrate the discrete interactions between angiogenic factors and cytokines in chronic inflammation and suggest that the sponge model is a good means for the study of such interactions.