ACTN3 R577X Genotype is Associated with Sprinting in Elite Japanese Athletes
ACTN3 R577X Genotype is Associated with Sprinting in Elite Japanese Athletes
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DOI：
10.1055/s-0033-1347171
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发表时间：
2014-02-01
影响因子：
2.5
通讯作者：
Tanaka, M.
中科院分区：
文献类型：
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作者：
Mikami, E.;Fuku, N.;Tanaka, M.
ACTN3 R577X基因型与所有精英运动员的冲刺/力量表型相关。这种关联尚未在亚洲优秀运动员中得到广泛研究。本研究旨在调查ACTN3 R577X基因型与日本优秀田径运动员状态之间的关系。对299名日本优秀田径运动员（134名短跑/力量运动员，165名耐力/中等力量运动员）和649名日本对照进行了ACTN3 R577X多态性基因分型。所有运动员均为国家级或国际级运动员。短跑/力量运动员的RR+RX基因型频率高于对照组（111/134[82.8%]比478/649 [73.7%]，r优势模型下P=0.025），耐力/中等力量运动员与对照组无显著差异（126/165[76.4%]比478/649 [73.7%]，r优势模型下P=0.48）。带有RR+RX基因型的短跑运动员在100米跑中个人最好成绩显著快于带有XX基因型的短跑运动员（10.42 +/- 0.05s vs. 10.64 +/- 0.09s， P=0.042）；在400米短跑运动员中没有发现这种关联（47.02 +/- 0.36秒vs. 47.56 +/- 0.99秒，P=0.62）。ACTN3 R577X基因型与日本优秀田径运动员的冲刺/力量表现有关，尤其是短跑成绩。
The ACTN3 R577X genotype has been found to associate with sprint/power phenotypes in all elite athlete cohorts investigated. This association has not been extensively studied in elite Asian athletes. The present study was undertaken to investigate the association between the ACTN3 R577X genotype and elite Japanese track and field athlete status. 299 elite Japanese track and field athletes (134 sprint/power athletes; 165 endurance/middle-power athletes) and 649 Japanese controls were genotyped for the ACTN3 R577X polymorphism. All athletes were of national or international level. Sprint/power athletes showed a higher frequency of RR+RX genotype than controls (111/134 [82.8%] vs. 478/649 [73.7%], P=0.025 under the R-dominant model), while there was no significant difference between endurance/middle-power athletes and controls (126/165 [76.4%] vs. 478/649 [73.7%], P=0.48 under the R-dominant model). Sprinters with the RR+RX genotype had significantly faster personal best times for the 100m than those with XX genotype (10.42 +/- 0.05s vs. 10.64 +/- 0.09s, P=0.042); no such association was found in the 400m sprinters (47.02 +/- 0.36s vs. 47.56 +/- 0.99s, P=0.62). ACTN3 R577X genotype is associated with sprint/power performance in elite Japanese track and field athletes, especially short sprint performance.