Elderly male smokers with right lung tumors are viable candidates for KRAS mutation screening.
Elderly male smokers with right lung tumors are viable candidates for KRAS mutation screening.
复制标题
患有右肺肿瘤的老年男性吸烟者是 KRAS 突变筛查的可行候选者
DOI：
10.1038/srep18566
复制
发表时间：
2016-01-07
影响因子：
4.6
通讯作者：
Jiang G
中科院分区：
文献类型：
--
作者：
Yang Y;Shi C;Sun H;Yin W;Zhou X;Zhang L;Jiang G
肿瘤驱动基因中的遗传畸变为治疗干预提供了特异性分子靶标，这可以大大改善治疗结果。本文分析EGFR、KRAS基因突变频率及EML 4-ALK重排情况，总结中国肺癌患者的临床病理特征。我们检测了1033例原发性肺癌患者的突变谱。分析的临床病理参数包括性别、诊断时的年龄、吸烟状况、病理TNM分期、肿瘤形态和位置、脏层胸膜侵犯和组织学类型。共有618例患者存在EGFR或KRAS基因突变以及EML 4-ALK重排。EGFR基因第19外显子缺失和L 858 R是最常见的突变。左侧肺癌在携带KRAS突变的女性患者中更常见。EML 4-ALK重排在非吸烟男性患者中更常见，他们也表现出更高的内脏胸膜侵袭可能性。从不吸烟且右侧有1-20 mm I期腺癌的老年女性EGFR突变频率较高。患有右肺肿瘤的老年男性吸烟者是KRAS突变筛查的可行候选人。
Genetic aberrations in tumor driver genes provide specific molecular targets for therapeutic intervention, which can greatly improve therapeutic outcomes. Here, we analyzed the mutational frequency of EGFR and KRAS gene, as well as EML4-ALK rearrangement, and summarized the clinicopathological characters of Chinese lung cancer patients. We detected the mutation spectrum of 1033 primary lung cancer patients. The analyzed clinicopathological parameters included gender, age at diagnosis, smoking status, pathological TNM stage, tumor morphology and location, visceral pleural invasion, and histological type. A total of 618 patients had mutations in EGFR or KRAS gene as well as rearrangement of EML4-ALK. Exon 19 deletions and L858R in the EGFR gene were the most frequent mutations. Left-side lung cancer was more common in female patients carrying the KRAS mutation. Rearrangement of EML4-ALK was more common in non-tobacco-using male patients, who also exhibited a higher likelihood of visceral pleura invasion. Elderly females who never smoked and possessed 1–20 mm stage I adenocarcinomas in the right side exhibited a higher frequency of EGFR mutations. Elderly male smokers with right lung tumors were viable candidates for KRAS mutation screening.