Lycorine: a potential broad-spectrum agent against crop pathogenic fungi.
Lycorine: a potential broad-spectrum agent against crop pathogenic fungi.
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DOI：
10.4014/jmb.1310.10063
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发表时间：
2014-03
影响因子：
2.8
通讯作者：
Jin-Wen Shen;Y. Ruan;Wei Ren;B. Ma;Xiaolong Wang;Chun-Feng Zheng
中科院分区：
文献类型：
--
作者：
Jin-Wen Shen;Y. Ruan;Wei Ren;B. Ma;Xiaolong Wang;Chun-Feng Zheng
筛选试验表明，石蒜碱分别在500μg/ml和100μg/ml浓度下对24种作物病原真菌表现出显着的抗真菌活性。通过观察其菌丝形态并研究其电导率的变化，选择禾谷镰刀菌进行抗真菌机制研究。此外，还对禾谷镰刀菌的物质吸收和代谢进行了探索。其机制被揭示为石蒜碱破坏细胞膜，进一步影响物质吸收和细胞代谢。
A screening test showed that lycorine exhibited significant antifungal activity against 24 pathogenic crop fungi at concentrations of 500 μg/ml and 100 μg/ml, respectively. Fusarium graminearum was selected for antifungal mechanism studies by observing its mycelial morphology and investigating the variations in its conductivity. In addition, the substance absorption and metabolism of F. graminearum were explored. The mechanism was revealed as being one by which lycorine destroyed the cellular membrane and further influenced substance absorption and cell metabolism.