Associations between human milk oligosaccharides and growth in infancy and early childhood
Associations between human milk oligosaccharides and growth in infancy and early childhood
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DOI：
10.1093/ajcn/nqaa010
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发表时间：
2020-04-01
影响因子：
7.1
通讯作者：
Bode, Lars
中科院分区：
文献类型：
--
作者：
Lagstrom, Hanna;Rautava, Samuli;Bode, Lars
背景：母乳喂养调节婴儿的生长和防止肥胖的发展。然而，母乳成分的母体变异，如母乳低聚糖（HMOs），是否与儿童生长计划有关，仍然未知。目的：我们的目的是确定在生命的前5个月，母亲的HMO组成和儿童生长之间的关系。此外，还评估了孕妇孕前BMI与HMO组成之间的关系。方法：来自802名母亲的母乳样本来自芬兰图尔库进行的一项前瞻性人群出生队列研究，即儿童健康发展的步骤（Steps）。用高效液相色谱法分析了牛奶样品中HMO的组成。从3个月至5岁的儿童生长数据从市级健康婴儿诊所收集，并与产妇HMO组成数据相关联，以检测相关性。结果：分泌型母亲分娩后3个月的产妇HMO成分与婴儿出生后5年的身高和体重有关。具体来说，HMO多样性和乳酸-n -新四糖（LNnT）的浓度呈负相关，2'-聚焦乳糖（2' fl）的浓度与儿童身高和体重z分数直接相关，该模型调整了母亲孕前BMI、分娩方式、出生体重z分数、性别和时间。孕妇孕前BMI与HMO组成相关。结论：母亲HMO组成与儿童生长之间的关联可能意味着一种因果关系，这需要在临床前和临床研究中进行额外的测试，特别是因为2'FL和LNnT是目前添加到婴儿配方奶粉中的HMO。此外，HMO成分的改变可能会介导孕妇孕前BMI对儿童肥胖的影响，值得进一步研究以建立因果关系。
Background: Breastfeeding modulates infant growth and protects against the development of obesity. However, whether or not maternal variation in human milk components, such as human milk oligosaccharides (HMOs), is associated with programming of child growth remains unknown.Objective: Our objective was to determine the association between maternal HMO composition and child growth during the first 5 y of life. In addition, the association between maternal prepregnancy BMI and HMO composition was assessed.Methods: Human milk samples from 802 mothers were obtained from a prospective population-based birth cohort study, Steps to healthy development of Children (STEPS), conducted in Turku, Finland. HMO composition in these milk samples was analyzed by HPLC. Child growth data from 3 mo to 5 y were collected from municipal well-baby clinics and linked to maternal HMO composition data to test for associations.Results: Maternal HMO composition 3 mo after delivery was associated with height and weight during the first 5 y of life in children of secretor mothers. Specifically, HMO diversity and the concentration of lacto-N-neo-tetraose (LNnT) were inversely associated and that of 2'-fucosyllactose (2'FL) was directly associated with child height and weight z scores in a model adjusted for maternal prepregnancy BMI, mode of delivery, birthweight z score, sex, and time. Maternal prepregnancy BMI was associated with HMO composition.Conclusions: The association between maternal HMO composition and childhood growth may imply a causal relation, which warrants additional testing in preclinical and clinical studies, especially since 2'FL and LNnT are among the HMOs now being added to infant formula. Furthermore, altered HMO composition may mediate the impact of maternal prepregnancy BMI on childhood obesity, which warrants further investigation to establish the cause-and-effect relation.