Effects of prolonged stress on salivary cortisol and dehydroepiandrosterone: A study of a two-week teaching practice
Effects of prolonged stress on salivary cortisol and dehydroepiandrosterone: A study of a two-week teaching practice
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DOI：
10.1016/j.psyneuen.2011.10.001
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发表时间：
2012-06-01
影响因子：
3.7
通讯作者：
Nomura, Shinobu
中科院分区：
文献类型：
--
作者：
Izawa, Shuhei;Saito, Keisuke;Nomura, Shinobu
本研究调查了唾液皮质醇和脱氢表雄酮（DHEA）水平的变化在一个长期的紧张局势（两周的教学实践）。33名女性在幼儿园进行了为期两周的教学实践，被要求在四个时间点收集唾液样本：觉醒时，觉醒后30分钟，睡前：实践前两周，实践的第一周，实践的第二周，实践后的几天。此外，他们每天都要完成评估压力和主观情绪的问卷。一个线性混合模型表明，皮质醇水平显着增加，在第一和第二周的做法相比，那些之前和之后的实践期间，和DHEA水平显着下降后的实践期间相比，在其他时间点。此外，皮质醇觉醒反应在练习期后显着降低，与其他时间点相比。在练习期间，感知压力和消极情绪的得分也较高。这项研究表明，长期的压力会影响皮质醇和DHEA的分泌过程中，以及压力期间后。(C)2011爱思唯尔有限公司版权所有。
This study investigated variations in salivary levels of cortisol and dehydroepiandrosterone (DHEA) in a prolonged stressful situation (a two-week teaching practice). Thirty-three women for whom a two-week teaching practice at a kindergarten was scheduled were asked to collect saliva samples at awakening, 30 min after awakening, and bedtime at four time points: two weeks before the practice, the first week of the practice, the second week of the practice, and a few days after the practice. In addition, they completed questionnaires for assessing perceived stress and subjective moods on each day. A linear mixed model indicated that cortisol levels significantly increased during the first and second week of the practice compared with those before and after the practice period, and that DHEA levels significantly decreased after the practice period compared with those at the other time points. Further, cortisol awakening response after the practice period significantly reduced compared with that at the other time points. Scores of perceived stress and negative moods were also higher during the practice period. This study showed that prolonged stress affected cortisol and DHEA secretion during as well as after the stress period. (C) 2011 Elsevier Ltd. All rights reserved.