HYPONATREMIA AND CEREBRAL INFARCTION IN PATIENTS WITH RUPTURED INTRACRANIAL ANEURYSMS - IS FLUID RESTRICTION HARMFUL
HYPONATREMIA AND CEREBRAL INFARCTION IN PATIENTS WITH RUPTURED INTRACRANIAL ANEURYSMS - IS FLUID RESTRICTION HARMFUL
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DOI：
10.1002/ana.410170206
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发表时间：
1985-01-01
影响因子：
11.2
通讯作者：
VANGIJN, J
中科院分区：
文献类型：
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作者：
WIJDICKS, EFM;VERMEULEN, M;VANGIJN, J
回顾性分析134例动脉瘤性蛛网膜下腔出血患者低钠血症与脑梗死的关系。44例患者在出血后第2 ~ 10天至少连续2天钠水平低于135 mmol/l。其中符合抗利尿激素分泌不当综合征的标准。44例低钠血症患者中有27例发生脑梗死，90例血清钠水平正常的患者中有19例发生脑梗死（P < 0.001）。低钠血症患者脑梗死死亡率更高（P < 0.01）。在44例患者中，26例患者接受了限液治疗以纠正血清钠水平，21例患者发生了梗死。在动脉瘤性蛛网膜下腔出血患者中，限制液体以纠正低钠血症似乎是潜在的危险。
The relationship between hyponatremia and cerebral infarction was studied retrospectively in 134 consecutive patients with aneurysmal subarachnoid hemorrhage. In 44 patients Na levels fell below 135 mmol/l on at least 2 consecutive days between the 2nd and the 10th day after the hemorrhage. Of these patients fulfilled the criteria for the syndrome of inappropriate secretion of antidiuretic hormone. Cerebral infarction developed in 27 of the 44 patients with hyponatremia and in 19 of the 90 patients with normal serum Na levels (P < 0.001). Cerebral infarctions were more often fatal in patients with hyponatremia (P < 0.01). Of the 44 patients, 26 had been treated with fluid restriction to correct the serum Na levels, and infarctions developed in 21. Fluid restriction to correct hyponatremia appears to be potentially dangerous in patients with aneurysmal subarachnoid hemorrhage.