Mechanism of interleukin-2 signaling: mediation of different outcomes by a single receptor and transduction pathway.
Mechanism of interleukin-2 signaling: mediation of different outcomes by a single receptor and transduction pathway.
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IL-2 信号传导机制：通过单一受体和转导途径介导不同结果。
DOI：
10.1126/science.2492678
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Koshland,ME
中科院分区：
文献类型：
--
作者：
Tigges,MA;Casey,LS;Koshland,ME
T细胞淋巴因子白细胞介素-2（IL-2）通过刺激抗原活化的B淋巴细胞在细胞周期中进展并分化成抗体分泌细胞而在免疫应答中起关键作用。IL-2诱导型B淋巴瘤系的生长和分化反应是不偶联的，它提供了一个模型系统来剖析在每种反应中运作的信号传导机制。该系统用于显示两种信号都是由IL-2与单个单功能受体复合物结合引发的。此外，这两种信号通过不涉及任何已知的第二信使系统的途径转导，并且可以被第二T细胞淋巴因子白细胞介素4阻断。这些发现表明，IL-2的多效性效应是由细胞核中信号的不同翻译决定的。
The T cell lymphokine, interleukin-2 (IL-2), plays a pivotal role in an immune response by stimulating antigen-activated B lymphocytes to progress through the cell cycle and to differentiate into antibody-secreting cells. An IL-2 inducible B lymphoma line, in which the growth and differentiation responses are uncoupled, provides a model system for dissecting the signaling mechanisms operating in each response. This system was used to show that both signals are initiated by IL-2 binding to a single, unifunctional receptor complex. Moreover, both signals are transduced by a pathway that does not involve any known second messenger system and that can be blocked by a second T cell lymphokine, interleukin 4. These findings suggest that the pleiotrophic effects of IL-2 are determined by different translations of the signal in the nucleus.