Halothane, enflurane, and isoflurane depress the peripheral vagal motor pathway in isolated canine tracheal smooth muscle.
Halothane, enflurane, and isoflurane depress the peripheral vagal motor pathway in isolated canine tracheal smooth muscle.
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氟烷、安氟烷和异氟烷抑制离体犬气管平滑肌的外周迷走神经运动通路。
DOI：
10.1097/00000542-199102000-00020
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发表时间：
1991
期刊：
影响因子：
8.8
通讯作者：
Rehder,K
中科院分区：
文献类型：
--
作者：
Brichant,JF;Gunst,SJ;Warner,DO;Rehder,K
挥发性麻醉剂是有效的支气管扩张剂，但扩张的作用部位尚不清楚。为了确定氟烷、安氟烷和异氟烷对外周迷走神经运动通路的作用位点，在暴露于 0.3、1.0、1.7 或 2.4 MAC 的氟烷、1 MAC 的安氟烷或 1 MAC 的异氟烷之前和期间刺激分离的犬气管肌条。刺激部位和方法为： 1) 壁内副交感神经节内的突触后烟碱胆碱能受体，用 1, 1-二甲基-4-苯基哌嗪碘化物 (DMPP)； 2）节后胆碱能神经纤维，采用电场刺激（EFS）； 3) 平滑肌的毒蕈碱胆碱能受体，包括乙酰胆碱 (ACh)。 0.3 MAC 氟烷对 DMPP 的浓度-响应曲线显着右移，而 0.3 MAC 氟烷对 ACh 和 EFS 的浓度-响应曲线没有显着影响。当氟烷、安氟烷或异氟烷的浓度大于 1 MAC 时，所有三种刺激物的浓度-反应曲线均显着向右移动；即，对ACh、EFS和DMPP的收缩反应降低。在所有氟烷浓度下，DMPP 刺激期间的收缩力比 ACh 刺激期间的收缩力显着降低更多，并且在氟烷浓度大于或等于 1.7 MAC 时，对 EFS 的反应比对 ACh 的反应显着降低更多。我们得出结论，氟烷、安氟烷和异氟烷通过多种机制减弱气道收缩，包括 1) 降低壁内副交感神经节突触后烟碱受体的兴奋性和 2) 对平滑肌和/或毒蕈碱受体的影响。（摘要截短为 250 字）
Volatile anesthetics are potent bronchodilators, but the site of action for the dilation is unclear. To determine the site of action of halothane, enflurane, and isoflurane on the peripheral vagal motor pathway, isolated strips of canine trachealis muscle were stimulated before and during exposure to halothane at 0.3, 1.0, 1.7, or 2.4 MAC, enflurane at 1 MAC, or isoflurane at 1 MAC. The sites and methods of stimulation were: 1) postsynaptic nicotinic cholinergic receptors in the intramural parasympathetic ganglia, with 1, 1-dimethyl-4-phenyl-piperazinium iodide (DMPP); 2) postganglionic cholinergic nerve fibers, with electrical field stimulation (EFS); and 3) muscarinic cholinergic receptors of the smooth muscle, with acetylcholine (ACh). The concentration-response curve to DMPP was significantly shifted to the right by 0.3 MAC halothane, whereas 0.3 MAC halothane had no significant effect on the concentration-response curves to ACh and EFS. At concentrations greater than 1 MAC of halothane, enflurane, or isoflurane, concentration-response curves to all three stimuli were shifted significantly to the right; ie, the contractile responses to ACh, EFS, and DMPP were reduced. At all concentrations of halothane the force of contraction was significantly more reduced during stimulation with DMPP than during stimulation with ACh, and at halothane concentrations greater than or equal to 1.7 MAC the response to EFS was significantly more reduced than that to ACh. We conclude that halothane, enflurane, and isoflurane attenuated airway constriction by several mechanisms, including 1) reduced excitability of the postsynaptic nicotinic receptors of the intramural parasympathetic ganglia and 2) an effect on the smooth muscle and/or on the muscarinic receptors.(ABSTRACT TRUNCATED AT 250 WORDS)