Verbal retention lateralizes patients with unilateral temporal lobe epilepsy and bilateral hippocampal atrophy.
Verbal retention lateralizes patients with unilateral temporal lobe epilepsy and bilateral hippocampal atrophy.
复制标题
言语保留使单侧颞叶癫痫和双侧海马萎缩的患者偏向一侧。
DOI：
10.1046/j.1528-1157.2001.30200.x
复制
发表时间：
2001
期刊：
影响因子：
5.6
通讯作者：
Kuzniecky,R
中科院分区：
文献类型：
--
作者：
Sawrie,SM;Martin,RC;Gilliam,F;Knowlton,R;Faught,E;Kuzniecky,R
目的：研究术前语言保留的偏侧化效用在双侧海马atrophy言语保持的操作化的韦氏记忆量表的逻辑记忆百分比保持的子测试（LM%）。将患者分为（a）双侧海马体积正常，（B）单侧萎缩或（c）双侧萎缩组。使用两种不同的阈值（经验推导的阈值与标准阈值）根据LM%进行偏侧化。然后使用χ2、敏感性、阳性预测值和比值比按组检查LM%偏侧化。分析也分别在亚组的患者谁是癫痫发作后surgical.Results：平均LM%性能显着较低，左与右颞叶癫痫患者的子集与双侧海马萎缩（p = 0.018），但不是在患者的MRI正常（p = 0.918）或单侧萎缩（p = 0.087）。通过LM%正确定侧的几率从MRI正常患者的1.67增加到双侧海马萎缩患者的36.11。在双侧海马萎缩的患者中，LM%预测右侧和左侧偏侧的能力分别为100%和75%。类似的结果时，分析仅限于癫痫发作的患者surgery.Conclusions：术前言语保留LM%测量可能提供有意义的偏侧信息，患者难以通过MRI偏侧。
Purpose:To examine the lateralization utility of preoperative verbal retention in patients with and without bilateral hippocampal atrophy.Methods:The sample consisted of 74 patients with EEG‐defined unilateral temporal lobe epilepsy (TLE) who had also undergone volumetric magnetic resonance imaging (MRI). Verbal retention was operationalized by the Logical Memory percentage retention subtest (LM%) of the Wechsler Memory Scale. Patients were divided into groups with (a) bilaterally normal hippocampal volumes, (b) unilateral atrophy, or (c) bilateral atrophy. Two different thresholds (empirically derived vs. normative) were used to lateralize on the basis of LM%. LM% lateralization was then examined by group using χ2, sensitivity, positive predictive values, and odds ratios. Analyses were also conducted separately in the subset of patients who were seizure free after surgery.Results:Mean LM% performance was significantly lower in patients with left versus right TLE in the subset with bilateral hippocampal atrophy (p = 0.018), but not in patients with a normal MRI (p = 0.918) or unilateral atrophy (p = 0.087). The odds of a correct lateralization by LM% increased from 1.67 in patients with normal MRI to 36.11 in patients with bilateral hippocampal atrophy. The power of a right and left lateralization prediction by LM% was 100% and 75%, respectively, in patients with bilateral hippocampal atrophy. Similar results were obtained when analysis was restricted to patients who were seizure free after surgery.Conclusions:Preoperative verbal retention as measured by LM% may provide meaningful lateralization information in patients who are difficult to lateralize via MRI.