Beyond the Ribosome: Extra-translational Functions of tRNA Fragments.
Beyond the Ribosome: Extra-translational Functions of tRNA Fragments.
复制标题
超越核糖体：tRNA片段的翻译功能。
DOI：
10.4137/bmi.s35904
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发表时间：
2016
影响因子：
3.8
通讯作者：
Bemis LT
中科院分区：
文献类型：
--
作者：
Diebel KW;Zhou K;Clarke AB;Bemis LT
对小RNA的高通量测序研究揭示了生物样本中复杂的非编码RNA环境。早期的数据分析通常局限于microRNA，因为它们的调节性质和作为生物标记物的潜力；然而，更多类别的非编码RNA现在正在被识别。一类最初被排除在分析之外的片段是来自转移RNA(TRNAs)的片段，因为它们被认为是降解产物。最近，关键的细胞功能被归因于tRNA片段(TRFs)，它们在生命所有领域的保守已经推动它们成为一个新兴的科学研究领域。TRFs的生物发生机制目前正在被阐明，初步研究表明，tRNA分子的所有部分都产生了一系列不同的TRFs。这篇综述的目的是介绍目前已知的TRFs及其作为早期疾病检测生物标记物的潜力。
High-throughput sequencing studies of small RNAs reveal a complex milieu of noncoding RNAs in biological samples. Early data analysis was often limited to microRNAs due to their regulatory nature and potential as biomarkers; however, many more classes of noncoding RNAs are now being recognized. A class of fragments initially excluded from analysis were those derived from transfer RNAs (tRNAs) because they were thought to be degradation products. More recently, critical cellular function has been attributed to tRNA fragments (tRFs), and their conservation across all domains of life has propelled them into an emerging area of scientific study. The biogenesis of tRFs is currently being elucidated, and initial studies show that a diverse array of tRFs are generated from all parts of a tRNA molecule. The goal of this review was to present what is currently known about tRFs and their potential as biomarkers for the earlier detection of disease.