Prevalence and Clinical Relevance of IgE Sensitization to Profilin in Childhood: A Multicenter Study
Prevalence and Clinical Relevance of IgE Sensitization to Profilin in Childhood: A Multicenter Study
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DOI：
10.1159/000441222
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发表时间：
2015-01-01
影响因子：
2.8
通讯作者：
Matricardi, Paolo Maria
中科院分区：
文献类型：
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作者：
Asero, Riccardo;Tripodi, Salvatore;Matricardi, Paolo Maria
背景：对于儿童中植物全过敏原谱蛋白过敏的患病率和临床相关性知之甚少。目的：本研究旨在调查生活在不同地理区域的一大群不同年龄的意大利儿童中 profilin 致敏的患病率、危险因素和临床相关性。方法：对意大利三个主要地理区域的 16 个儿科门诊入组的花粉过敏儿童进行了研究。使用商业花粉提取物和商业纯化的枣椰花花粉谱进行 SPT。通过ImmunoCAP FEIA 测试了过敏花粉分子特异性的IgE、Phl p 12（草Profilin）和Pru p 3（桃脂质转移蛋白）。结果：1,271 名参与者中的 296 名参与者 (23%) 观察到 IgE 至 Phl p 12 (>= 0.35 kU/l)，其中包括 108 名学龄前儿童中的 17 名 (16%)。 320/1,271 (25%) 名参与者的 Profilin SPT 呈阳性（>= 3 mm）。两种诊断方法在 1,151 例 (91%, p < 0.0001) 病例中一致。从意大利北部到南部，Phl p 12 IgE 患病率呈下降趋势，并且与 IgE 达到 Phl p 1 和/或 Phl p 5 和 Ole e 1 直接相关。在 IgE 达到 Phl p 12 的儿童中，猕猴桃、甜瓜、西瓜、香蕉、杏和黄瓜会引发 OAS。结论：Profilin 致敏在花粉过敏儿童中非常常见，发生在很小的时候，并有助于儿童 OAS 的发展，具有典型的不良食物模式。儿科医生在检查花粉过敏儿童时，应始终考虑 IgE 对 Profinin 的敏感性，即使他们处于学龄前阶段。 (C) 2015 S. Karger AG，巴塞尔
Background: Little is known about the prevalence and clinical relevance of hypersensitivity to the plant panallergen profilin in children. Objectives: The present study aimed to investigate prevalence, risk factors and clinical relevance of profilin sensitization in a large cohort of Italian children of different ages living in different geographic areas. Methods: Children with pollen allergy enrolled by 16 pediatric outpatient clinics sited in three main geographic areas of Italy were studied. SPT were carried out with commercial pollen extracts and a commercial purified date palm pollen profilin. IgE specific for allergenic pollen molecules, Phl p 12 (grass profilin) and Pru p 3 (peach lipid transfer protein) were tested by ImmunoCAP FEIA. Results: IgE to Phl p 12 (>= 0.35 kU/l) was observed in 296 of the 1,271 participants (23%), including 17 of the 108 (16%) preschool children. Profilin SPT was positive (>= 3 mm) in 320/1,271 (25%) participants. The two diagnostic methods were concordant in 1,151 (91%, p < 0.0001) cases. Phl p 12 IgE prevalence declined from northern to southern Italy and was directly associated with IgE to Phl p 1 and/or Phl p 5 and Ole e 1. Among children with IgE to Phl p 12, OAS was provoked by kiwi, melon, watermelon, banana, apricot and cucumber. Conclusions: Profilin sensitization is very frequent among pollen-allergic children, occurs at a very young age and contributes to the development of childhood OAS with a typical pattern of offending foods. Pediatricians should always consider IgE sensitization to profilin while examining pollen-allergic children, even if they are at preschool age. (C) 2015 S. Karger AG, Basel