Cycling of Ca2+ across the Plasma Membrane as a Mechanism for Generating a Ca2+ Signal for Cell Activation a
Cycling of Ca2+ across the Plasma Membrane as a Mechanism for Generating a Ca2+ Signal for Cell Activation a
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Ca2 穿过质膜的循环作为产生细胞激活 Ca2 信号的机制
DOI：
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发表时间：
1989
影响因子：
5.2
通讯作者：
Wendy B. Bollag
中科院分区：
文献类型：
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作者：
H. Rasmussen;P. Barrett;W. Zawalich;C. Isales;P. Stein;J. Smallwood;Richard McCarthy;Wendy B. Bollag
当最初在神经和肌肉中进行Ca2+信使功能的研究时，Ca2+似乎以一种非常简单的方式发挥其信使作用：细胞内Ca2+浓度的增加和减少直接导致细胞活性的增加和减少。也就是说，CaZ+浓度的变化与细胞反应的变化有直接的对应关系。然而，随着对Ca2+信使功能的研究扩展到包括各种其他组织，很明显Ca2+信使系统比最初想象的要复杂得多。”在目前的讨论中，我们将简要介绍Ca信使功能的经典观点，然后考虑Ca和cAMP信使系统之间的亲密关系2。接下来将考虑Ca2+作为一种细胞毒素，以及Ca2+中毒威胁对Ca2+作为细胞内信使的使用施加的重要限制。最后，Ca2+信使功能的复杂性将通过讨论两个系统来强调：肾上腺肾小球细胞分泌醛固酮和β细胞分泌胰岛素在这个讨论的过程中，一个特殊的论点将被发展：在持续的细胞反应中，Ca2‘在质膜上的循环是一个特定的Ca2+信使的机制，在质膜的一个亚域内Ca2’浓度的增加，[Ca2+]…产生。这种Ca2+信使导致特定细胞反应的方式是由与质膜相关的Ca2+敏感换能器的性质和数量决定的。在许多情况下，为了使Ca2+信息有效，cAMP信使系统必须被适当地激活。
When studies of Ca2+ messenger function were initially carried out in nerve and muscle, it seemed that Ca2+ played its messenger role in a very simple manner: increases and decreases in intracellular Ca2+ concentration led directly to increases and decreases in cellular activity. That is, there was a direct correspondence between changes in CaZ+ concentration and changes in cellular response. However, as studies of Ca2+ messenger function expanded to include a variety of other tissues, it became evident that the Ca2+ messenger system is considerably more complex than originally envisioned.' In the present discussion, we will present a brief account of the classic view of Ca" messenger function, and then consider the intimate relationship between the Ca" and cAMP messenger systems2 This will be followed by a consideration of Ca2+ as a cellular toxin and the important constraint that the threat of Ca2+ intoxication imposes on the use of Ca2+ as intracellular messenger. Finally, the complexity of Ca2+ messenger function will be emphasized by discussing two systems: aldosterone secretion from adrenal glomerulosa cells and insulin secretion from beta cells.3 In the course of this discussion, a particular thesis will be developed: during sustained cellular responses, it is a cycling of Ca2' across the plasma membrane that is the mechanism by which a specific Ca2+ messenger, an increase in the Ca2' concentration in a subdomain of the plasma membrane, [Ca2+],,, is generated. The way in which this Ca2+ messenger leads to a specific cellular response is determined by the nature and number of the Ca2+-sensitive transducers associated with the plasma membrane. In many cases, the cAMP messenger system must be activated appropriately in order for the Ca2+ messages to be effective.
腺苷酸环化酶的刺激性 G 蛋白 Gs 也能刺激二氢吡啶敏感的 Ca2 通道。
DOI：
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发表时间：
1988
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Yatani,A;Imoto,Y;Codina,J;Hamilton,SL;Brown,AM;Birnbaumer,L
通讯作者：
Birnbaumer,L
蛋白激酶 C 对红细胞 Ca2 泵活性的调节。
DOI：
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发表时间：
1988
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Smallwood,JI;Gügi,B;Rasmussen,H
通讯作者：
Rasmussen,H