Lifestyle-related disease in Crohn's disease: Relapse prevention by a semi-vegetarian diet
Lifestyle-related disease in Crohn's disease: Relapse prevention by a semi-vegetarian diet
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DOI：
10.3748/wjg.v16.i20.2484
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发表时间：
2010-05-28
影响因子：
4.3
通讯作者：
Imai, Hideo
中科院分区：
文献类型：
--
作者：
Chiba, Mitsuro;Abe, Toru;Imai, Hideo
目的：探讨半素食饮食（SVD）是否有预防克罗恩病（CD）复发的效果，在患者谁已经达到缓解，谁是复发的高危人群。方法：前瞻性，单中心，2年的临床试验进行。22例通过药物（n = 17）或手术（n = 5）获得临床缓解并在住院期间服用SVD的成人CD患者被建议继续接受SVD治疗，并避免已知的炎症性肠病高风险食物。主要终点是临床复发，定义为CD活动性症状的出现。Kaplan-Meier生存分析用于计算复发患者的累积比例。一个为期2年的分析复发率的患者谁遵循SVD和那些谁没有（杂食饮食组）carried.RESULTS：SVD继续由16例（依从性73%）。SVD组16例患者中有15例（94%）维持缓解，杂食组6例患者中有2例（33%）维持缓解。1年时SVD缓解率为100%，2年时为92%。与杂食组相比，SVD在复发时间方面表现出显着的预防作用（P = 0.0003，对数秩检验）。在接受SVD治疗的缓解患者中，超过一半的患者在末次访视时C反应蛋白浓度正常，这些患者在研究期间维持缓解（9/15; 60%），终止随访（8/12; 67%），完成2年随访（7/10; 70%）。结论：SVD对CD的复发有明显的预防作用。(C)2010年百世登。All rights reserved.
AIM: To investigate whether semi-vegetarian diet (SVD) has a preventive effect against relapse of Crohn's disease (CD) in patients who have achieved remission, who are a high-risk group for relapse.METHODS: A prospective, single center, 2-year clinical trial was conducted. Twenty-two adult CD patients who achieved clinical remission either medically (n = 17) or surgically (n = 5) and consumed an SVD during hospitalization were advised to continue with an SVD and avoid known high-risk foods for inflammatory bowel disease. The primary endpoint was clinical relapse defined as the appearance of active symptoms of CD. Kaplan-Meier survival analysis was used to calculate the cumulative proportion of patients who had a relapse. A 2-year analysis of relapse rates of patients who followed an SVD and those who did not (an omnivorous diet group) was undertaken.RESULTS: SVD was continued by 16 patients (compliance 73%). Remission was maintained in 15 of 16 patients (94%) in the SVD group vs two of six (33%) in the omnivorous group. Remission rate with SVD was 100% at 1 year and 92% at 2 years. SVD showed significant prevention in the time to relapse compared to that in the omnivorous group (P = 0.0003, log rank test). The concentration of C-reactive protein was normal at the final visit in more than half of the patients in remission who were taking an SVD, who maintained remission during the study (9/15; 60%), who terminated follow-up (8/12; 67%), and who completed 2 years follow-up (7/10; 70%). There was no untoward effect of SVD.CONCLUSION: SVD was highly effective in preventing relapse in CD. (C) 2010 Baishideng. All rights reserved.