Chiral Amidophosphane-Rhodium(I)-Catalyzed Asymmetric Conjugate Arylation of Acyclic Enones with Arylboronic Acids
Chiral Amidophosphane-Rhodium(I)-Catalyzed Asymmetric Conjugate Arylation of Acyclic Enones with Arylboronic Acids
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DOI：
10.1248/cpb.57.1024
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发表时间：
2009-09-01
影响因子：
1.7
通讯作者：
Tomioka, Kiyoshi
中科院分区：
文献类型：
--
作者：
Chen, Qian;Kuriyama, Masami;Tomioka, Kiyoshi
在氢氧化钾存在下，在1，4-二氧六环和水的混合物中，在70 ℃下，用3mol%的手性氨基单膦1-铑（I）催化无环α，β-不饱和酮与芳基硼酸的催化不对称共轭芳基化，以高化学产率提供具有高对映体过量的1，4-共轭芳基化无环酮。反应的十三个实例证明了催化体系的普遍适用性。
A catalytic asymmetric conjugate arylation of acyclic alpha,beta-unsaturated ketones with arylboronic acids was catalyzed by 3 mol% of chiral amidomonophosphane 1-rhodium(I) in the presence of potassium hydroxide in a mixture of 1,4-dioxane and water at 70 degrees C to afford 1,4-conjugate arylated acyclic ketones with high enantiomeric excess in high chemical yield. Thirteen examples of the reaction demonstrate the general applicability of the catalytic system.