Stem and precursor cells in the nervous system.
Stem and precursor cells in the nervous system.
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DOI：
10.1089/089771504323004566
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发表时间：
2004-07
影响因子：
4.2
通讯作者：
M. Rao
中科院分区：
文献类型：
--
作者：
M. Rao
早期形成的神经管由增殖的、形态均质的细胞组成，称为“神经上皮（NEP）干细胞”，它们通过一系列中间前体细胞产生神经元、星形胶质细胞和少突胶质细胞。除了 NEP 细胞之外，第二类干细胞——神经球形成细胞——可以在发育的后期阶段分离出来。 NEP 细胞可以分化为神经嵴干细胞，进而产生三七总皂甙衍生物。 NEP 细胞和神经球形成干细胞以及更受限制的前体细胞表达可用于表征它们的特征性标记物谱。这些细胞类型中的每一种都可以从胚胎干 (ES) 细胞培养物中分离出来，它们的行为与在发育后期分离的细胞相似。讨论了这些细胞用于细胞替代疗法的相对优点和缺点。
The early-formed neural tube consists of proliferating, morphologically homogeneous cells, termed "neuroepithelial (NEP) stem cells" which generate neurons, astrocytes, and oligodenrocytes through a series of intermediate precursor cells. In addition to NEP cells, a second class of stem cells-the neurosphere-forming cell-can be isolated at later stages of development. NEP cells can differentiate into neural crest stem cells, which in turn generate PNS derivatives. NEP cells and neurosphereforming stem cells and more restricted precursors express a characteristic spectrum of markers that can be used to characterize them. Each of these cell types can be isolated from embryonic stem (ES) cell cultures, and their behavior appears similar to cells isolated at later developmental ages. The relative advantages and disadvantages of these cells for cell replacement therapy are discussed.