In-Vitro Demonstration of Ultra-Reliable, Wireless and Batteryless Implanted Intracranial Sensors Operated on Loci of Exceptional Points
In-Vitro Demonstration of Ultra-Reliable, Wireless and Batteryless Implanted Intracranial Sensors Operated on Loci of Exceptional Points
复制标题
在特殊点位点操作的超可靠、无线和无电池植入式颅内传感器的体外演示
DOI：
10.1109/tbcas.2022.3164697
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发表时间：
2022
影响因子：
5.1
通讯作者：
Chen, Pai-Yen
中科院分区：
文献类型：
--
作者：
Yang, Minye;Ye, Zhilu;Alsaab, Nabeel;Farhat, Mohamed;Chen, Pai-Yen
脉搏、呼吸频率、器官内和血管内压力等生命信号的监测可以为临床诊断、治疗和手术方案的制定提供重要信息。如今，配备有用于将生物信号转换为调制无线电传输的天线的微机械生物植入物可以允许远程连续监测患者的生命体征。然而，鉴于发射天线和接收天线之间不可避免的未对准，当前的无源生物遥测技术通常遭受差的信号再现性和鲁棒性。在这里，我们试图解决这个长期存在的挑战，并通过引入一种新型的，高性能的生物遥测系统，从无源无线颅内压（或脑压）传感器稳健地获取信息。尽管可变的感应链路，该生物遥测系统可以通过利用具有奇偶时间（PT）对称性的非厄米特射频（RF）电子系统中例外点（EP）的位点的唯一性来具有绝对准确性。我们的体外实验演示表明，所提出的颅内（ICP）监测系统可以在0-20 mmHg的ICP范围内提供亚mmHg分辨率，并提供超鲁棒的无线数据采集，以防止误操作引起的感应链路减弱。我们的研究结果可以提供一种实用的途径，实现对ICP以及生物植入物和可穿戴设备产生的其他重要信号的可靠、实时的无线监测。
Vital signal monitoring, such as pulse, respiration rate, intra-organ and intra-vascular pressure, can provide important information for determination of clinic diagnosis, treatments, and surgical protocols. Nowadays, micromachined bioimplants, equipped with antennas for converting bio-signals to modulated radio transmissions, may allow remote continuous monitoring of patients’ vital signs. Yet, current passive biotelemetry techniques usually suffer from poor signal reproducibility and robustness in light of inevitable misalignment between transmitting and receiving antennas. Here, we seek to address this long-existing challenge and to robustly acquire information from a passive wireless intracranial pressure (or brain pressure) sensor by introducing a novel, high-performance biotelemetry system. In spite of variable inductive links, this biotelemetry system may have absolute accuracy by leveraging the uniqueness of loci of exceptional points (EPs) in non-Hermitian radio-frequency (RF) electronic systems with parity-time (PT) symmetry. Our in-vitro experimental demonstration shows that the proposed intracranial (ICP) monitoring system can provide a sub-mmHg resolution in the ICP range of 0-20 mmHg and ultra-robust wireless data acquisition against the misalignment-induced weakening of inductive link. Our results could provide a practical pathway toward reliable, real-time wireless monitoring of ICP, and other vital signals generated by bio-implants and wearables.