INVIVO MEASUREMENT OF PROTON DIFFUSION IN THE PRESENCE OF COHERENT MOTION
INVIVO MEASUREMENT OF PROTON DIFFUSION IN THE PRESENCE OF COHERENT MOTION
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DOI：
10.1097/00004424-199106000-00006
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发表时间：
1991-06-01
影响因子：
6.7
通讯作者：
MAKI, JH
中科院分区：
文献类型：
--
作者：
JOHNSON, GA;MAKI, JH
组织中水的自扩散系数D的测量传统上使用Stejskal和坦纳提出的技术进行。 这里显示了该技术的一种变体，采用流量补偿梯度，显著降低了对身体成像中常见的小相干运动的灵敏度。 具有扩散敏感梯度（B）的四个值的交错序列使配准误差最小化。 涡流和其他系统误差减少，允许在文献中的非成像值的5%内的成像环境中的标准的测量。 流量补偿序列允许测量大鼠腹腔中组织的D。 我们目前在体内测量D为以下大鼠组织：肝，肾（皮质），肾（髓质）肌肉，脑，脂肪。
Measurement of the self-diffusion coefficient D of water in tissue has been performed traditionally using the technique proposed by Stejskal and Tanner. A variant of that technique is shown here, employing flow-compensated gradients that significantly reduce the sensitivity to small coherent motions that are common in body imaging. An interleaved sequence with four values of diffusion-sensitizing gradient (b) minimizes registration errors. Eddy currents and other systematic errors are reduced, permitting the measurement of standards in an imaging context within 5% of nonimaging values in the literature. The flow-compensated sequence permits the measure of D for tissues in the abdominal cavity of the rat. We present in vivo measurements of D for the following rat tissues: liver, kidney (cortex), kidney (medulla) muscle, brain, fat.