Defining the neural mechanisms of probabilistic reversal learning using event-related functional magnetic resonance imaging
Defining the neural mechanisms of probabilistic reversal learning using event-related functional magnetic resonance imaging
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DOI：
10.1523/jneurosci.22-11-04563.2002
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发表时间：
2002-06-01
影响因子：
5.3
通讯作者：
Robbins, TW
中科院分区：
文献类型：
--
作者：
Cools, R;Clark, L;Robbins, TW
在13名年轻健康的人类志愿者执行一项概率反转学习任务期间，使用事件相关功能磁共振成像来测量血氧水平依赖反应。该任务允许对刺激 - 奖励关联的重新学习以及负反馈的接收进行单独研究。当受试者停止对先前相关刺激做出反应并转向对新相关刺激做出反应时，在试验中右侧腹外侧前额叶皮质显示出显著的信号变化。通过感兴趣区域分析，在这种反转错误时，腹侧纹状体区域也观察到显著的信号变化。腹外侧前额叶皮质和腹侧纹状体在其他先前的反转错误时，或者当受试者因正确反应而收到负反馈时，没有显著激活。此外，在转变之前的最后一次反转错误的反应不受先前反转错误次数的调节，这表明与错误相关的活动并非简单地在这个网络中累积。因此，这个腹侧额 - 纹状体回路中的信号变化与反转学习相关，并且未受负反馈的污染。总体而言，这些数据与啮齿动物和非人灵长类动物在腹侧额 - 纹状体回路受损后出现反转学习缺陷的研究结果一致，并且也支持使用该任务的近期临床发现。
Event-related functional magnetic resonance imaging was used to measure blood oxygenation level-dependent responses in 13 young healthy human volunteers during performance of a probabilistic reversal-learning task. The task allowed the separate investigation of the relearning of stimulus-reward associations and the reception of negative feedback. Significant signal change in the right ventrolateral prefrontal cortex was demonstrated on trials when subjects stopped responding to the previously relevant stimulus and shifted responding to the newly relevant stimulus. Significant signal change in the region of the ventral striatum was also observed on such reversal errors, from a region of interest analysis. The ventrolateral prefrontal cortex and ventral striatum were not significantly activated by the other, preceding reversal errors, or when subjects received negative feedback for correct responses. Moreover, the response on the final reversal error, before shifting, was not modulated by the number of preceding reversal errors, indicating that error-related activity does not simply accumulate in this network. The signal change in this ventral frontostriatal circuit is therefore associated with reversal learning and is uncontaminated by negative feedback. Overall, these data concur with findings in rodents and nonhuman primates of reversal-learning deficits after damage to ventral frontostriatal circuitry, and also support recent clinical findings using this task.