ABNORMAL RESPONSE OF TUMOR VASCULATURE TO VASOACTIVE DRUGS
ABNORMAL RESPONSE OF TUMOR VASCULATURE TO VASOACTIVE DRUGS
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DOI：
10.1093/jnci/72.1.145
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发表时间：
1984-01-01
期刊：
影响因子：
--
通讯作者：
LAMAR, CH
中科院分区：
文献类型：
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作者：
CHAN, RC;BABBS, CF;LAMAR, CH
本文研究了血管收缩剂苯肾上腺素和血管扩张剂肼苯哒嗪对肿瘤血流量的影响，并与对正常组织血流量的影响进行了比较。在150- 250-g近交系哈兰F344大鼠中使用放射性微球测量局部血流量和心输出量，该大鼠带有两种类型的可移植癌（“硬”和“软”）的皮下结节，具有显微镜下不同的血管模式。三组大鼠分别用肼苯哒嗪、生理盐水或苯丙氨酸治疗，并在最大血压反应时测定局部血流量。结果与肿瘤和正常组织中小动脉和毛细血管壁厚度的定量形态学分析相关。心输出量显示苯丙氨酸减少，肼苯哒嗪增加正常组织灌注。肿瘤血流量仍然很低，并没有显着影响药物治疗，除了苯乙哌啶对硬肿瘤的影响。肿瘤血管壁的组织学研究显示缺乏能够通过收缩或扩张对血管活性药物作出反应的平滑肌。显然，血管活性药物通过对正常血管的选择性作用，可以改变肿瘤组织与正常组织的灌注比例。特别是，血管扩张药物增加正常组织：肿瘤血流量可能会增强局部热疗的选择性。
The effects of the vasoconstrictor phenylephrine and the vasodilator hydralazine on blood flow to tumor were studied and compared to those on blood flow to normal tissues in vivo. Regional blood flow and cardiac output were measured with the use of radioactive microspheres in 150- to 250-g inbred Harlan F344 rats bearing subcutaneous nodules of two types of transplantable carcinoma (“hard” and “soft”) with microscopically different vascular patterns. Three groups of rats were treated with hydralazine, saline, or phenylephrine, and regional blood flow was determined at the time of maximum blood pressure response. Results were correlated with quantitative morphometric analysis of arteriolar and capillary wall thickness in tumor and normal tissue. Phenylephrine decreased and hydralazine increased normal tissue perfusion as indicated by cardiac output. Tumor blood flow remained low and was not significantly influenced by drug treatment, except for the phenylephrine effect on hard tumors. Histologic study of tumor vessel walls revealed an absence of smooth muscle capable of responding to the vasoactive drugs by constriction or dilation. Evidently, by their selective action on normal vessels, vasoactive drugs can change the ratio of tumornormal tissue perfusion. In particular, the increase of normal tissue:tumor blood flow by vasodilator drugs may enhance the selectivity of local heat therapy.