Depressive disease: a genetic study.
Depressive disease: a genetic study.
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抑郁症：基因研究。
作者：
G. Winokur;R. Cadoret;J. Dorzab;M. Baker
研究人员对100名抑郁症先证者进行了检查。获得了每个先证者的家族史，并对这些先证者的129个主要亲属进行了家庭研究。对基因数据的分析支持至少存在两种类型的抑郁症的可能性。其中一种可能被称为“抑郁症谱系疾病”。这种情况的原型是40岁之前发病的女性，在她的家庭中，女性亲属比男性亲属更容易患抑郁症，而男性的缺陷则由酗酒和反社会行为来弥补。第二个原型是纯粹的抑郁症，先证者是一名男性，他的疾病开始于40岁之后，男性和女性亲属都有等量的抑郁症，男性没有大量的酗酒或反社会行为。
One hundred depressive probands have been examined. A family history was obtained on each of the probands, and a family study was done on 129 primary relatives of these probands. An analysis of the genetic data is in favor of the possibility that at least two types of depressive illness exist. One of these may be called "depression spectrum disease." The prototype of this would be a female with an onset prior to age 40 in whose family more depression is seen in female relatives than male relatives and the deficit in males is made up by alcoholism and sociopathy. The second prototype is that of pure depressive disease in which the proband is a male whose illness starts after age 40 and in whom there are equal amounts of depression in both male and female relatives and no large amount of alcoholism or sociopathy in the males.