Effect of auditory stimulus on executive function and execution time during cognitively demanding stepping task in patients with Parkinson's disease.
Effect of auditory stimulus on executive function and execution time during cognitively demanding stepping task in patients with Parkinson's disease.
复制标题
听觉刺激对帕金森病患者认知要求较高的步进任务执行功能和执行时间的影响。
DOI：
10.1016/j.neulet.2018.03.032
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发表时间：
2018
期刊：
影响因子：
2.5
通讯作者：
Nojima I.
中科院分区：
文献类型：
--
作者：
Watanabe T;Saito K;Ishida K;Tanabe S;Horiba M;Itamoto S;Ueki Y;Wada I;Nojima I.
帕金森病(PD)患者的开始犹豫主要发生在分心和冲突的情况下。本研究的目的是研究听觉刺激(AS)对PD患者在认知要求较高的步进任务中的执行功能和执行时间的影响与健康对照组相比有何不同。帕金森病患者和健康对照组对箭头的视觉命令刺激做出了反应。我们应用了一个包含一致和不一致条件的Simon任务。在一致的情况下，箭头的方向和位置是匹配的，而在不一致的情况下，它们不匹配。AS与视觉刺激随机且同时呈现。分析了预期姿势调整(APA)方向的错误，称为APA错误，以及时间参数(APA的反应开始和APA持续时间)。结果显示，无论在何种条件下，AS均增加了对照组的APA错误率，但对PD组的APA错误率无明显影响。AS还加快了两组的反应开始，无论情况如何。AS延长了对照组的APA时程，而对PD组的APA时程无明显影响。这些发现表明，AS可以促进步进的启动，可以想象是通过促进刺激识别过程和增加对步进行为的注意控制，而不会影响PD患者的决策过程，即使在认知要求很高的情况下也是如此。
Start hesitation in patients with Parkinson’s disease (PD) occurs predominantly during distractive and conflictual situations. The aim of this study was to investigate how differently an auditory stimulus (AS) influences execution function and execution time during a cognitively demanding stepping task in PD patients as compared to healthy controls. PD patients and healthy controls stepped forward in response to a visual imperative stimulus of an arrow. We applied a Simon task that comprised congruent and incongruent conditions. Direction and location of the arrow matched in the congruent condition, while they didn’t in the incongruent condition. AS were randomly and simultaneously presented with the visual stimulus. An error in the direction of an anticipatory postural adjustment (APA), termed an APA error, and temporal parameters (reaction onset of APA and APA duration) were analyzed. As a result, the AS increased the APA error rate in the control group regardless of the condition, but they did not influence it in the PD group. The AS also speeded the reaction onset in both groups regardless of the condition. The APA duration was prolonged by the AS for the control group, while it was unaffected by the AS for the PD group in both conditions. These findings indicate that AS could facilitate a step initiation, conceivably by facilitating a stimulus identification process and increasing attentional control of stepping behavior, without influencing a decision-making process even in a cognitively demanding condition in patients with PD.