Development of rodent macrovibrissae: effects of neonatal whisker denervation and bilateral neonatal enucleation.
Development of rodent macrovibrissae: effects of neonatal whisker denervation and bilateral neonatal enucleation.
复制标题
啮齿动物大触须的发育：新生儿胡须去神经和双侧新生儿摘除的影响。
DOI：
10.1080/08990220600700784
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发表时间：
2006
影响因子：
0.9
通讯作者：
PhilipZeigler,H
中科院分区：
文献类型：
--
作者：
Landers,Margo;Haidarliu,Sebastian;PhilipZeigler,H
在本文中，我们描述了在新生大鼠中操纵两种感觉输入对大触觉--啮齿类动物肌间触觉的活动亚群--发育的影响。在对正常胡须发育的初步研究中，有关胡须大小的数据来自新生、围产期和成年大鼠。有关胡须大小的数据也来自于接受胡须感觉或运动去神经的大鼠，以及作为新生儿的大鼠和小鼠的双侧去核(BEN)。在正常饲养的大鼠中，大多数胡须在出生后三周内达到最终尺寸，但第六和第七排的发育直到第一个月之后才完成。在正常动物中，我们发现体重和胡须的大小以及胡须的大小和相应的皮质桶的大小之间存在显着的相关性。与正常饲养的动物相比，新生的胡须失神经的大鼠成年后的胡须更短、更细。在双侧去核的大鼠和小鼠中，新生大鼠的大触觉的一个子集明显大于正常对照组，但如果在成人中进行去核，则没有看到这种影响。此外，暴露在新的刺激环境中的本老鼠比正常饲养的动物跳动的频率要高得多。对可能调节这些影响的机制进行了讨论。
In this paper we describe the effects of manipulating two kinds of sensory input in neonatal rats upon the development of the macrovibrissae—that movable subset of the rodent mystacial vibrissae. In an initial study of normal whisker development, data on whisker size were obtained from neonatal, perinatal, and adult rats. Data on whisker size were also obtained from rats sustaining either neonatal sensory or motor denervation of the whiskers and from both rats and mice bilaterally enucleated as neonates (BEN). In normally reared rats, most whiskers attain their final size over the first three postnatal weeks but development of rows 6 and 7 are not completed until after the first month. In normal animals we found a significant correlation both between body weight and whisker size and between the size of a whisker and the size of its corresponding cortical barrel. Rats sustaining neonatal denervation of the whiskers have shorter and thinner whiskers as adults than normally reared animals. In both rats and mice bilaterally enucleated as neonates a subset of the macrovibrissae are significantly larger than those of normal controls but no such effect is seen if the enucleation is carried out in adults. Moreover, BEN rats exposed to a novel stimulus environment whisk at a significantly higher frequency than normally reared animals. Mechanisms which might mediate these effects are discussed.