High-density lipoprotein cholesterol and apolipoprotein A-I levels at diagnosis in patients with non-insulin dependent diabetes
High-density lipoprotein cholesterol and apolipoprotein A-I levels at diagnosis in patients with non-insulin dependent diabetes
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DOI：
10.1007/bf00252761
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发表时间：
1981-05
期刊：
影响因子：
8.2
通讯作者：
K. G. Taylor;A. Wright;T. J. Carter;A. Valente;S. Betts;K. Matthews
中科院分区：
文献类型：
--
作者：
K. G. Taylor;A. Wright;T. J. Carter;A. Valente;S. Betts;K. Matthews
当非胰岛素依赖型糖尿病患者与性别、年龄、肥胖、饮酒和吸烟的对照人群进行匹配时，诊断时的高密度脂蛋白（HDL）胆固醇水平降低。血清 HDL-胆固醇浓度与糖化血红蛋白 A1 (HbA1) 百分比之间没有关联。糖尿病患者的血清高密度脂蛋白胆固醇水平在整个血清甘油三酯水平范围内较低，尤其是高甘油三酯血症糖尿病患者。在血清甘油三酯水平正常的糖尿病患者中，血清载脂蛋白A-I水平没有降低，因此糖尿病患者中HDL胆固醇与载脂蛋白A-I的比率显着降低（p<0.005）。非胰岛素依赖型糖尿病中高密度脂蛋白胆固醇水平的降低可能与动脉粥样硬化的后续发展有关。
High-density lipoprotein (HDL) cholesterol levels were decreased in patients with non-insulin dependent diabetes at diagnosis when matched with a control population for sex, age, obesity, alcohol consumption and cigarette smoking. There was no association between serum HDL-cholesterol concentration and the percentage of glycosylated haemoglobin A1(HbA1). Serum HDL-cholesterol levels were lower in diabetics over the whole range of serum triglyceride levels, and particularly in hypertriglyceridaemic diabetics. Serum apolipoprotein A-I levels were not decreased in diabetics with normal serum triglyceride levels, so that the ratio of HDL cholesterol to apolipoprotein A-I was significantly decreased in diabetics (p<0.005). Decreased HDL cholesterol levels in non-insulin dependent diabetes could be relevant to the subsequent development of atherosclerosis.