Acute liver failure of unknown pathogenesis: The hidden agenda
Acute liver failure of unknown pathogenesis: The hidden agenda
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发病机制不明的急性肝功能衰竭：隐藏的议程
DOI：
10.1002/hep.1840190532
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发表时间：
1994
期刊：
影响因子：
13.5
通讯作者：
E. Fagan
中科院分区：
文献类型：
--
作者：
E. Fagan
大部分散发的ALF病例病因不明（以前称为NANB肝炎）。PCR等敏感分子生物学技术的应用表明，少数病例可能是由于一种或多种已知的促肝药物（如HBV和HCV）的隐性感染。越来越多的证据表明，至少有一种潜在的新型和传染性病原体（候选F型肝炎）是有罪的。在发病机制不明的ALF中，尽管最近医疗管理有所改善，但不进行移植的存活率仍低于20%。通过对移植后复发性肝炎的深入研究，可以进一步了解ALF的可能病因以及感染因子与宿主之间的相互作用。对潜在病因的持续研究似乎可以根据可能的病因进行分层。这种科学的方法应该为未来的治疗选择提供合理的基础。
A major proportion of sporadic cases of ALF remain of uncertain cause (formerly termed NANB hepatitis). The application of sensitive molecular biology techniques such as PCR indicates that a few cases may be due to cryptic infections with one or more known hepatotropic agents, such as HBV and HCV. Evidence continues to accumulate to incriminate at least one potentially novel and transmissible agent (candidate hepatitis F). In ALF of unknown pathogenesis, survival without transplantation remains less than 20% despite recent improvements in medical management. Close study of recurrent hepatitis after grafting may provide further clues to the possible causes of ALF and the interaction between infectious agent and host. The continued pursuit of potential causes seems justified to allow stratification according to possible pathogeneses. This scientific approach should provide a rational basis for future therapeutic options.
与暴发性肝炎有关的乙型肝炎病毒前核心突变体的完整核苷酸序列及其在黑猩猩中的生物学特征。
影响因子：
3.7
作者：
Ogata,N;Miller,RH;Ishak,KG;Purcell,RH
通讯作者：
Purcell,RH
DOI：
10.1001/jama.1992.03480150057037
发表时间：
1992-04
期刊：
JAMA
影响因子：
--
作者：
J. Hibbs;N. Frickhofen;S. Rosenfeld;S. Feinstone;S. Kojima;A. Bacigalupo;A. Locasciulli;A. Tzakis;H. Alter;N. Young
通讯作者：
J. Hibbs;N. Frickhofen;S. Rosenfeld;S. Feinstone;S. Kojima;A. Bacigalupo;A. Locasciulli;A. Tzakis;H. Alter;N. Young