Comparison of time-intensity-curve- (TIC-) analysis of contrast-enhanced ultrasound (CEUS) and dynamic contrast-enhanced (DCE) MRI for postoperative control of microcirculation in free flaps - First results and critical comments
Comparison of time-intensity-curve- (TIC-) analysis of contrast-enhanced ultrasound (CEUS) and dynamic contrast-enhanced (DCE) MRI for postoperative control of microcirculation in free flaps - First results and critical comments
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DOI：
10.3233/ch-2011-1399
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发表时间：
2011-01-01
影响因子：
2.1
通讯作者：
Jung, E. M.
中科院分区：
文献类型：
--
作者：
Fellner, C.;Prantl, L.;Jung, E. M.
术后监测移植的游离皮瓣是发现可能的并发症的重要手段。本研究的目的是比较基于对比增强(CEUS)和动态对比增强(DCE)磁共振成像(MRI)灰阶数据的时间-强度-曲线(TIC-)分析的价值。对11例游离皮瓣移植患者进行术后成像，在CEUS和DCE MRI数据相同的感兴趣区(ROI)进行TIC分析。在皮瓣内的一个或两个不同位置对浅(0-1 cm)、中(1-2 cm)和深(2-3 cm)感兴趣区进行了微循环评估，共评估了46个感兴趣区(在非常薄的皮瓣中，仅评估了浅和中感兴趣区)。在这两种成像方法中，正常血流的ROI(n=40)的平均信号增加显著高于微循环受损的ROI(n=6)。虽然TIC分析可以量化皮瓣不同区域的微循环，但在这项初步研究中，没有明确的阈值来区分微循环正常和受损的皮瓣。
Postoperative monitoring of transplanted free flaps is an essential tool to reveal possible complications. The aim of this study was to compare the value of time-intensity-curve-(TIC-) analysis based on grey scale data of contrast-enhanced ultrasound (CEUS) and dynamic contrast-enhanced (DCE-) magnetic resonance imaging (MRI). Postoperative imaging was performed in 11 patients following free flap transplantation and TIC analysis was obtained in identical regions of interest (ROI) of CEUS and DCE MRI data. Microcirculation was assessed in superficial (0-1 cm), middle (1-2 cm), and deep (2-3 cm) ROIs in one or two different positions within the flap resulting in a total of 46 ROIs evaluated (in very thin flaps only superficial and middle ROIs were assessed). For both imaging methods, mean signal increase was found to be significantly higher in ROIs of normally perfused flaps (n = 40) compared to ROIs with compromised microcirculation (n = 6). Although TIC analysis allows quantification of microcirculation in different regions of the flap, in this preliminary study no distinct threshold could be defined to differentiate flaps with normal and compromised microcirculation.