HLA ANTIGENS AND INTRACRANIAL ANEURYSMS
HLA ANTIGENS AND INTRACRANIAL ANEURYSMS
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DOI：
10.1007/bf01541246
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发表时间：
1992-01-01
影响因子：
2.4
通讯作者：
GORSKI, A
中科院分区：
文献类型：
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作者：
RYBA, M;GRIEB, P;GORSKI, A
在颅内动脉瘤破裂后3天内死于蛛网膜下腔出血的59名移植供体（SAH组）中测定HLA-A、-B和-DR的频率，并与389名死于其他原因的供体组成的对照组进行比较。唯一的显著差异是在SAH组中与DR 7表型相关的非分型（“空”）-DR基因座的频率增加。对这一发现最可能的解释是在SAH组中DR 7纯合子的频率比一般人群高几倍。而携带纯合子形式的DR 7等位基因与发生潜在致命性颅内出血的极高风险相关。
The frequencies of the HLA-A, -B and -DR were determined in a group of 59 transplant donors who died from subarachnoid haemorrhage within three days following the rupture of intracranial aneurysm (the SAH group) and compared with those of a control group consisting of 389 donors who died from other causes. The only significant difference was in thc increased frequency in the SAH group of non-typed ("empty") -DR loci in association with the DR7 phenotype.The most probable explanation of this finding is that in the SAH group the frequency of DR7 homozygotes is several times higher than in the general population, and that bearing the DR7 allele in homozygotic form is associated with a very high risk of developing potentially fatal intracranial aneurysmal haemorrhage.