Atypical Chemokine Receptors and Their Roles in the Resolution of the Inflammatory Response.
Atypical Chemokine Receptors and Their Roles in the Resolution of the Inflammatory Response.
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DOI：
10.3389/fimmu.2016.00224
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发表时间：
2016
影响因子：
7.3
通讯作者：
Graham GJ
中科院分区：
文献类型：
--
作者：
Bonecchi R;Graham GJ
趋化因子及其受体是炎症过程的关键介质，调节白细胞外渗和定向迁移到发炎和感染的组织中。控制炎症组织中趋化因子的可用性对于获得解决环境是必要的，当这一点失败时，就会发生慢性炎症。因此，脊椎动物已经采用了许多机制来从发炎部位去除趋化因子以帮助沉淀消退。在过去的15年中，很明显，在这个过程中的重要参与者是非典型趋化因子受体（ACKR）家族的成员。一般来说，这个家族在基质细胞类型上表达，并清除趋化因子以限制其空间可用性或将其从体内位点去除。在这里，我们提供了一个简短的审查，这些ACKR和讨论他们参与的决议炎症反应和治疗的影响，我们目前的知识。
Chemokines and their receptors are key mediators of the inflammatory process regulating leukocyte extravasation and directional migration into inflamed and infected tissues. The control of chemokine availability within inflamed tissues is necessary to attain a resolving environment and when this fails chronic inflammation ensues. Accordingly, vertebrates have adopted a number of mechanisms for removing chemokines from inflamed sites to help precipitate resolution. Over the past 15 years, it has become apparent that essential players in this process are the members of the atypical chemokine receptor (ACKR) family. Broadly speaking, this family is expressed on stromal cell types and scavenges chemokines to either limit their spatial availability or to remove them from in vivo sites. Here, we provide a brief review of these ACKRs and discuss their involvement in the resolution of inflammatory responses and the therapeutic implications of our current knowledge.