Individual differences in threat sensitivity predict serotonergic modulation of amygdala response to fearful faces
Individual differences in threat sensitivity predict serotonergic modulation of amygdala response to fearful faces
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DOI：
10.1007/s00213-005-2215-5
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发表时间：
2005-08-01
影响因子：
3.4
通讯作者：
Robbins, TW
中科院分区：
文献类型：
--
作者：
Cools, R;Calder, AJ;Robbins, TW
理论基础：在这项研究中，我们使用功能磁共振成像(FMRI)来检测急性色氨酸耗竭(ATD)对恐惧面孔大脑激活的影响。急性色氨酸耗竭(ATD)是一种公认的诱导短暂性脑5-羟色胺耗竭的方法。目的：我们预测ATD将增加杏仁核对恐惧面孔的反应，这是威胁敏感度个体差异的函数。方法：12名健康男性志愿者采用双盲交叉设计，服用色氨酸耗竭饮料或色氨酸平衡氨基酸饮料(安慰剂)。在饮酒5小时后，参与者接受了扫描，同时看着恐惧、高兴和中性的面孔。结果：与以前的研究结果一致，恐惧面孔在双侧杏仁核/海马体、梭形脸部区域和右侧背外侧前额叶皮质引起了显著的信号变化。此外，ATD通过自我报告的威胁敏感性(用行为抑制量表测量；Carver CS，White TL(1994)行为抑制、行为激活以及对即将到来的奖惩的情感反应：BIS/BAS量表)调节杏仁核/海马体对恐惧和快乐面孔的反应的激活。J Pers Soc心理学67：319-333)。结论：这些数据支持这样的假设，即威胁敏感性的个体差异与5-羟色胺功能的操纵相互作用，从而使杏仁核依赖的威胁相关刺激的加工产生偏差。
Rationale: In this study we used functional magnetic resonance imaging (fMRI) to examine the effects of acute tryptophan depletion (ATD), a well-recognised method for inducing transient cerebral serotonin depletion, on brain activation to fearful faces. Objectives: We predicted that ATD would increase the responsiveness of the amygdala to fearful faces as a function of individual variation in threat sensitivity. Methods: Twelve healthy male volunteers received a tryptophan depleting drink or a tryptophan balancing amino acid drink (placebo) in a double-blind crossover design. Five hours after drink ingestion participants were scanned whilst viewing fearful, happy and neutral faces. Results: Consistent with previous findings, fearful faces induced significant signal change in the bilateral amygdala/hippocampus as well as the fusiform face area and the right dorsolateral prefrontal cortex. Furthermore, ATD modulated amygdala/hippocampus activation in response to fearful relative to happy faces as a function of self-reported threat sensitivity (as measured with the Behavioral Inhibition Scale; Carver CS, White TL (1994) Behavioral inhibition, behavioral activation, and affective responses to impending reward and punishment: the BIS/BAS scales. J Pers Soc Psychol 67:319-333). Conclusion: The data support the hypothesis that individual variation in threat sensitivity interacts with manipulation of 5-HT function to bias the processing of amygdala-dependent threat-relevant stimuli.