Gateways of ventral and dorsal streams in mouse visual cortex.
Gateways of ventral and dorsal streams in mouse visual cortex.
复制标题
小鼠视觉皮层中腹侧和背面的网关。
DOI：
10.1523/jneurosci.3488-10.2011
复制
发表时间：
2011-02-02
期刊：
影响因子：
--
通讯作者：
Burkhalter A
中科院分区：
文献类型：
--
作者：
Wang Q;Gao E;Burkhalter A
人们普遍认为，啮齿动物导航的空间处理功能与人类情景记忆的编码功能相似。空间和非空间信息由包括视觉在内的所有感官提供。有人认为，视觉输入通过背侧和腹侧皮质内流馈送到皮质和海马中的导航网络，但这在啮齿动物中尚未直接显示。我们已经使用细胞和chemoarchitectonic标记，地形图的感受野和路径跟踪，以确定在小鼠视觉皮层是否lateromedial（LM）和前外侧领域（AL），这是主要的目标，初级视觉皮层（V1）专门用于处理非空间和空间视觉信息，是不同的领域与不同的连接。我们已经发现，LM/AL边界与第4层中2型毒蕈碱乙酰胆碱受体（m2 AChR）表达的变化和下视野周边的表示相一致。我们的定量分析进一步表明，LM强烈的投射到颞叶皮层以及外侧内嗅皮层，这具有弱的空间选择性。相反，AL与后顶叶皮层、运动皮层和空间选择性内侧内嗅皮层有较强的联系。这些结果支持的概念，LM和AL的结构，地形和连接不同的区域的纹外视皮层，它们是网关的腹侧和背侧流。
It is widely held that the spatial processing functions underlying rodent navigation are similar to those encoding human episodic memory. Spatial and nonspatial information are provided by all senses including vision. It has been suggested that visual inputs are fed to the navigational network in cortex and hippocampus through dorsal and ventral intracortical streams, but this has not been shown directly in rodents. We have used cyto- and chemoarchitectonic markers, topographic mapping of receptive fields and pathway tracing to determine in mouse visual cortex whether the lateromedial (LM) and the anterolateral fields (AL), which are the principal targets of primary visual cortex (V1) specialized for processing nonspatial and spatial visual information, are distinct areas with diverse connections. We have found that the LM/AL border coincides with a change in type 2 muscarinic acetylcholine receptor (m2AChR) expression in layer 4 and with the representation of the lower visual field periphery. Our quantitative analyses further show that LM strongly projects to temporal cortex as well as the lateral entorhinal cortex, which has weak spatial selectivity. In contrast, AL has stronger connections with posterior parietal cortex, motor cortex and the spatially selective medial entorhinal cortex. These results support the notion that LM and AL are architecturally, topographically and connectionally distinct areas of extrastriate visual cortex and that they are gateways for ventral and dorsal streams.