Protein-recruiting synthetic molecules targeting the Golgi surface
Protein-recruiting synthetic molecules targeting the Golgi surface
复制标题
靶向高尔基体表面的蛋白质招募合成分子
DOI：
10.1039/d0cc06908f
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发表时间：
2020
影响因子：
4.9
通讯作者：
Tsukiji Shinya
中科院分区：
文献类型：
--
作者：
Sawada Shunsuke;Nakamura Akinobu;Yoshii Tatsuyuki;Kuwata Keiko;Nakatsu Fubito;Tsukiji Shinya
细胞器定位小分子配体是控制活细胞中蛋白质定位和信号过程的宝贵工具。在这里，我们提出了专门定位于高尔基表面的合成配体。该配体可从细胞质中快速募集靶蛋白到高尔基体，并可用于调控高尔基膜上的信号蛋白和脂质，为研究和控制高尔基体/细胞功能提供了一种新的有用的化学工具。
Organelle-localizable small-molecule ligands are valuable tools for spatiotemporally controlling protein localization and signaling processes in living cells. Here, we present synthetic ligands that specifically localize to the Golgi surface. The ligands can rapidly recruit their target proteins from the cytoplasm to the Golgi and be applied to manipulate signaling proteins and lipids on the Golgi membrane, offering a new useful chemical tool for the study and control of Golgi/cell functions.