The tale of histone modifications and its role in multiple sclerosis.
The tale of histone modifications and its role in multiple sclerosis.
复制标题
DOI：
10.1186/s40246-018-0163-5
复制
发表时间：
2018-06-22
期刊：
影响因子：
4.5
通讯作者：
Yang B
中科院分区：
文献类型：
--
作者：
He H;Hu Z;Xiao H;Zhou F;Yang B
表观遗传学定义了基因表达的持续修饰，其方式不涉及DNA序列的相应改变。它包括DNA核苷酸的修饰、核小体重塑和翻译后修饰（PTM）。越来越明显的是，PTM单独或组合作用形成“组蛋白密码”，协调染色质结构和动态功能。组蛋白尾部的PTM已被证明影响许多生物学发展以及疾病的发作和进展。多发性硬化（MS）是一种中枢神经系统的自身免疫性、炎性脱髓鞘和神经退行性疾病，其确切的病理生理机制尚未完全阐明。有大量新出现的证据表明，表观遗传修饰可能会带来MS的风险，这为MS提供了新的见解。组蛋白PTMs，调节基因激活的关键事件之一，似乎在MS的表观遗传机制中发挥了突出的作用。在这篇综述中，我们总结了最近的研究，在我们理解的表观遗传语言，包括组蛋白，特别强调组蛋白乙酰化和组蛋白赖氨酸甲基化，这是两种最佳表征的组蛋白修饰。我们还讨论了目前的研究如何解决组蛋白乙酰化和组蛋白赖氨酸甲基化影响MS的病理生理学，以及未来的研究如何设计以建立MS的优化治疗策略。
Epigenetics defines the persistent modifications of gene expression in a manner that does not involve the corresponding alterations in DNA sequences. It includes modifications of DNA nucleotides, nucleosomal remodeling, and post-translational modifications (PTMs). It is becoming evident that PTMs which act singly or in combination to form “histone codes” orchestrate the chromatin structure and dynamic functions. PTMs of histone tails have been demonstrated to influence numerous biological developments, as well as disease onset and progression. Multiple sclerosis (MS) is an autoimmune inflammatory demyelinating and neurodegenerative disease of the central nervous system, of which the precise pathophysiological mechanisms remain to be fully elucidated. There is a wealth of emerging evidence that epigenetic modifications may confer risk for MS, which provides new insights into MS. Histone PTMs, one of the key events that regulate gene activation, seem to play a prominent role in the epigenetic mechanism of MS. In this review, we summarize recent studies in our understanding of the epigenetic language encompassing histone, with special emphasis on histone acetylation and histone lysine methylation, two of the best characterized histone modifications. We also discuss how the current studies address histone acetylation and histone lysine methylation influencing pathophysiology of MS and how future studies could be designed to establish optimized therapeutic strategies for MS.
登录
查看更多内容
影响因子：
5.3
作者：
Deckert, J;Struhl, K
通讯作者：
Struhl, K
影响因子：
12.3
作者：
Dillon SC;Zhang X;Trievel RC;Cheng X
通讯作者：
Cheng X
DOI：
10.3109/10409238.2011.619164
发表时间：
2011-12
影响因子：
6.5
作者：
Blus BJ;Wiggins K;Khorasanizadeh S
通讯作者：
Khorasanizadeh S
影响因子：
56.9
作者：
Jacobson, RH;Ladurner, AG;Tjian, R
通讯作者：
Tjian, R
影响因子：
4.4
作者：
Fischer, Jenny J.;Toedling, Joern;Sperling, Silke
通讯作者：
Sperling, Silke