CHANGES IN THE BRONCHIAL EPITHELIUM IN RELATION TO SMOKING AND CANCER OF THE LUNG - A REPORT OF PROGRESS
CHANGES IN THE BRONCHIAL EPITHELIUM IN RELATION TO SMOKING AND CANCER OF THE LUNG - A REPORT OF PROGRESS
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DOI：
10.1056/nejm195701172560301
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发表时间：
1957-01-01
影响因子：
158.5
通讯作者：
STOUT, AP
中科院分区：
文献类型：
--
作者：
AUERBACH, O;GERE, JB;STOUT, AP
本文对117例气管支气管树进行了组织学观察，除因病理原因丢失的气管支气管树共208段。这些病例被分为两组：死于肺癌(34例)的患者，均为吸烟者；死于非肺癌原因的患者。后者根据吸烟史分为3类：从不经常吸烟或从不吸烟者(16例)、每天吸烟量少于一包的患者(20例)和每天吸烟超过一包的患者(47例)。评估了上皮的四种变化：基底细胞增生、复层、鳞状化生和原位癌。在死于肺癌以外的其他原因的人中，从不经常吸烟的人中，基底细胞增生、层化、鳞状化生和原位癌的发生率最低，而中度和重度吸烟者的比例逐渐增加。在谁死于肺癌中也看到了同样但更广泛的变化。虽然在所有人群中都存在明确的原位癌，且随香烟消费量的增加而成比例上升，但在每天吸一包以上香烟的人(6.0%)和肺癌患者(6.3%)中，这种变化的分布几乎相似。这一发现与一种或另一种吸入剂是导致肺癌的重要因素的假设完全一致。
The histologic observations were recorded on 117 cases in which the tracheo-bronchial tree was divided into 208 sections except for those lost for pathologic reasons. The cases were divided into 2 groups: those who died of bronchogenic carcinoma (34 patients), all of whom were smokers; and those who died of causes other than bronchogenic carcinoma. The findings in the latter group were tabulated according to their smoking histories, which were divided into 3 categories[long dash]those who never smoked regularly or at all (16 patients), those who smoked under one package a day (20 patients) and those who smoked more than one package a day (47 patients). Four changes in the epithelium were evaluated: basal-cell hyperplasia; stratification; squamous metaplasia; and carcinoma-in-situ. Among people who died of causes other than lung cancer, basal-cell hyperplasia, stratification, squamous metaplasia and carcinoma-in-situ were least frequent in the group that never smoked regularly, with a progressive increase in the moderate and heavy smokers. The same but more extensive changes were seen in whose who died of carcinoma of the lung. Although definite carci-noma-in-situ was present in all groups, with a parallel rise in proportion to increasing cigarette consumption, there was an almost similar distribution of this change in those who smoked more than one package a day (6.0%) and in the cases of bronchogenic carcinoma (6.3%). The findings are fully consistent with the hypothesis that inhalants of one sort or another are important factors in the causation of bronchogenic carcinoma.