Apolipoprotein E genotypes in stroke patients from urban Tanzania.
Apolipoprotein E genotypes in stroke patients from urban Tanzania.
复制标题
坦桑尼亚城市中风患者的载脂蛋白 E 基因型。
DOI：
10.1016/j.jns.2022.120331
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发表时间：
2022
影响因子：
4.4
通讯作者：
Mateen,FarrahJ
中科院分区：
文献类型：
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作者：
Rice,DylanR;Vogel,AndreC;Ismail,SeifS;Okeng'o,Kigocha;Lugemwa,GraceK;Henry,Jonathan;Kourkoulis,Christina;Mateen,FarrahJ
结果100名参与者(女性56%，男性44%；入选时平均年龄=58.5岁，标准差=15.0岁，范围19-90岁)中，48人患有缺血性中风，52人患有出血性中风。常见的合并症(根据≥报告的10%的参与者)是高血压(n=84)、糖尿病(n=23)、中风史(n=20)、肥胖(n=19)和吸烟(n=11)。19%的人没有接受过教育；69%的人接受过小学到中学的教育；12%的人接受过讨论我们提供了一个坦桑尼亚中风患者队列中关于载脂蛋白E基因型别的新数据。我们论证了在LMIC中采集的中风患者全血样本的提取、存储和远程基因组分析的可行性。虽然有28个样品无法分析，但可以在提取、处理、储存和样品转移方面进行工艺改进，以提高未来结果的产率。
ResultsOf 100 participants (56% female, 44% male; mean age at enrollment= 58.5 years, standard deviation= 15.0 years, range 19–90 years), 48 had ischemic strokes, and 52 had hemorrhagic strokes. Common comorbidities (reported by≥ 10% of participants) were hypertension (n= 84), diabetes (n= 23), history of stroke (n= 20), obesity (n= 19), and cigarette smoking (n= 11). Nineteen percent had received no education; 69% had received primary to some secondary school level of education; and 12% hadDiscussionWe present novel data on ApoE genotypes in a convenience cohort of Tanzanian stroke patients. We demonstrate the feasibility of the extraction, storage, and remote genomic analysis of stroke patients' whole blood samples, collected in a LMIC. Although 28 samples were unable to be analyzed, process improvements in extraction, handling, storage, and sample transfer could be undertaken to improve the yield of results in the future.