Prevention of neurotoxicity in hypoxic cortical neurons by the noble gas xenon
Prevention of neurotoxicity in hypoxic cortical neurons by the noble gas xenon
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DOI：
10.1016/s0024-3205(02)02439-6
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发表时间：
2003-03-14
期刊：
影响因子：
6.1
通讯作者：
Kox, WJ
中科院分区：
文献类型：
--
作者：
Petzelt, C;Blom, P;Kox, WJ
在 N-2 或氙气氛中对胚胎大鼠皮层神经元进行了缺氧诱导的神经元损伤和谷氨酸释放的研究；在 N-2 处理的细胞中观察到细胞损伤和谷氨酸过度释放，而氙则保护细胞免受缺氧损伤。用钙螯合剂 BAPTA-AM 预孵育神经元，会大大降低氙的保护作用，这表明钙在此过程中发挥了作用。结果证明了（a）氙的神经保护特性，表明（b）在缺氧情况下预防神经递质释放与神经保护之间的关系，并提出（c）证据表明这种神经保护可能基于其他氙依赖性机制。 (C) 2003 年，爱思唯尔科学公司出版。
Hypoxia-induced neuronal damage and glutamate release were investigated in a N-2- or in xenon-atmosphere for embryonic rat cortical neurons; cellular damage and glutamate over-release were observed in N-2-treated cells whereas xenon protected the cells from the hypoxic insult. The protective effect of xenon was strongly reduced by pre-incubating neurons with the calcium-chelator BAPTA-AM indicating a role for calcium in this process. The results demonstrate (a) the neuroprotective properties of xenon, suggest (b) a relationship between the prevention of neurotransmitter release in a hypoxic situation and neuroprotection and present (c) evidence that such neuroprotection may be based on yet other xenon-dependent mechanisms. (C) 2003 Published by Elsevier Science Inc.