Cutting edge: Transplant tolerance induced by anti-CD45RB requires B lymphocytes
Cutting edge: Transplant tolerance induced by anti-CD45RB requires B lymphocytes
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DOI：
10.4049/jimmunol.178.10.6028
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发表时间：
2007-05-15
影响因子：
4.4
通讯作者：
Markmann, James F.
中科院分区：
文献类型：
--
作者：
Deng, Shaoping;Moore, Daniel J.;Markmann, James F.
mAb（抗CD 45 RB）对CD 45 RB同种型的选择性干扰可靠地诱导供体特异性耐受。虽然以前的研究表明调节性T细胞的参与，抗CD 45 RB诱导的耐受机制的理解是缺乏的。我们在此报告了一个意外的发现，即在B细胞缺陷小鼠中未建立由该试剂诱导的耐受性，但可通过将B淋巴细胞转移至B细胞缺陷宿主而恢复B。使用来自基因修饰供体的B细胞重建B细胞缺陷受体，我们评估了B淋巴细胞表达的CD 45 RB、T细胞共刺激分子和Ab的产生在这种新的耐受机制中的作用。我们的数据证明了Ab诱导的耐受方案是独特的B淋巴细胞依赖性的，并表明B细胞隔室通过与T细胞的相互作用对耐受性发展的机制性贡献。免疫学杂志，2007，178：6028-6032.
Selective interference with the CD45RB isoform by mAb (anti-CD45RB) reliably induces donor-specific tolerance. Although previous studies suggest participation of regulatory T cells, a mechanistic understanding of anti-CD45RB-induced tolerance is lacking. We report herein the unexpected finding that tolerance induced by this agent is not established in B cell-deficient mice but can be recovered b preemptive B lymphocyte transfer to B cell-deficient hosts. Using B cells from genetically modified donors to reconstitute B cell-deficient recipients, we evaluate the role of B lymphocyte-expressed CD45RB, T cell costimulatory molecules, and the production of Abs in this novel tolerance mechanism. Our data document an Ab-induced tolerance regimen that is uniquely B lymphocyte-dependent and suggest mechanistic contributions to tolerance development from the B cell compartment through interactions with T cells. The Journal of Immunology, 2007, 178: 6028-6032.