Electrospray Ionization Tandem Mass Spectrometry of Phosphonate Peptides
Electrospray Ionization Tandem Mass Spectrometry of Phosphonate Peptides
复制标题
DOI：
10.1255/ejms.1072
复制
发表时间：
2010-02
影响因子：
1.3
通讯作者：
Zhenyu Zheng;Yan Liu;Z. Cai;Han-Wen Zhang;H. Fang;M. Fang;Yufen Zhao
中科院分区：
文献类型：
--
作者：
Zhenyu Zheng;Yan Liu;Z. Cai;Han-Wen Zhang;H. Fang;M. Fang;Yufen Zhao
采用正离子电喷雾质谱联用串联质谱法合成膦酸酯肽。结果表明，对于钠化加合物，存在两个重排反应。路径A中，C-C共价键断裂，一个氢原子连续迁移，失去氨基醇分子。在路径B中，C-N和P-O键发生了两个连续的共价断裂。
Phosphonate peptides were synthesized and investigated by positive ion electrospray ionization mass spectrometry in conjunction with tandem mass spectrometry. It was found that, for the sodiated adduct, there were two rearrangement reactions. In path A, there was C–C covalent bond cleavage with consecutive migration of a hydrogen atom to lose the amino alcohol molecule. In path B, two consecutive covalent cleavages of the C–N and P–O bonds occurred.