Ligand accelerated indium(III)-catalyzed asymmetric alkynylation of aldehydes with 2-methyl-3-butyn-2-ol as an ethyne equivalent donor
Ligand accelerated indium(III)-catalyzed asymmetric alkynylation of aldehydes with 2-methyl-3-butyn-2-ol as an ethyne equivalent donor
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DOI：
10.1039/b614958h
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发表时间：
2007-03-07
影响因子：
4.9
通讯作者：
Shibasaki, Masakatsu
中科院分区：
文献类型：
--
作者：
Harada, Shinji;Takita, Ryo;Shibasaki, Masakatsu
以2-甲基-3-丁基-2-醇为乙烷当量供体，铟（III）催化芳基、杂芳基、烷基和烯基醛的不对称炔基化反应，在2-10 mol%的催化剂条件下，得到了中高收率（97%）和高对映选择性（99% ee）的产物。
Indium(III)-catalyzed asymmetric alkynylation of aryl, heteroaryl, alkyl and alkenyl aldehydes with 2-methyl-3-butyn-2-ol as an ethyne equivalent donor was realized, and products were obtained in moderate to good yields (up to 97%) and high enantioselectivities (up to 99% ee) using 2-10 mol% of catalyst.