Epidemiology of alcoholic and nonalcoholic fatty liver disease in China
Epidemiology of alcoholic and nonalcoholic fatty liver disease in China
复制标题
中国酒精性和非酒精性脂肪肝流行病学
DOI：
10.1111/jgh.12036
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发表时间：
2013-08-01
影响因子：
4.1
通讯作者：
Fan, Jian-Gao
中科院分区：
文献类型：
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作者：
Fan, Jian-Gao
过去二十年来，中国脂肪肝（FLD）患者的患病率大约增加了一倍。目前，FLD在中国非常流行（约占城市人口的27%），通常通过影像学诊断，并且主要与肥胖和代谢综合征（MetS）有关。然而，临床上慢性肝病患者中酒精性肝病（ALD）的比例也在不断增加，并且酒精性肝病与肥胖之间存在协同效应。患病率数据揭示了地区差异，ALD 和非酒精性 FLD (NAFLD) 的中位患病率分别为 4.5% 和 15.0%。儿童 NAFLD 的患病率为 2.1%，但肥胖儿童的患病率增至 68.2%。随着肥胖和代谢综合征在普通人群中的日益流行，中国可能会存在越来越多的FLD患者。 FLD 的危险因素与白人相似，但肥胖和 MetS 的种族特定定义对于评估中国人更有用。因此，FLD/NAFLD已成为我国最常见的慢性肝病。需要采取公共卫生干预措施来阻止全球肥胖和酗酒的趋势，以减轻肝损伤并改善代谢健康。
The prevalence of patients presenting with fatty liver disease (FLD) in China has approximately doubled over the past two decades. At present, FLD, which is typically diagnosed by imaging, is highly prevalent (similar to 27% urban population) in China and is mainly related to obesity and metabolic syndrome (MetS). However, the percentage of alcoholic liver disease (ALD) among patients with chronic liver diseases in clinic is increasing as well, and a synergetic effect exists between heavy alcohol drinking and obesity in ALD. Prevalence figures reveal regional variations, with a median prevalence of ALD and nonalcoholic FLD (NAFLD) of 4.5% and 15.0%, respectively. The prevalence of NAFLD in children is 2.1%, although the prevalence increases to 68.2% among obese children. With the increasing pandemic of obesity and MetS in the general population, China is likely to harbor an increasing reservoir of patients with FLD. The risk factors for FLD resemble to those of Caucasian counterparts, but the ethnic-specific definitions of obesity and MetS are more useful in assessment of Chinese people. Therefore, FLD/NAFLD has become a most common chronic liver disease in China. Public health interventions are needed to halt the worldwide trend of obesity and alcohol abuse to ameliorate liver injury and to improve metabolic health.