Candidate-gene association analysis of response to risperidone in African-American and white patients with schizophrenia
Candidate-gene association analysis of response to risperidone in African-American and white patients with schizophrenia
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DOI：
10.1038/tpj.2009.24
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发表时间：
2009-10-01
影响因子：
2.8
通讯作者：
Houston, J. P.
中科院分区：
文献类型：
--
作者：
Fijal, B. A.;Kinon, B. J.;Houston, J. P.
临床试验数据评估了22个单核苷酸多态性（snp）与口服利培酮治疗的精神分裂症、分裂情感性障碍或精神分裂症样障碍急性患者的反应之间的关系。探索性（78名非裔美国人）和验证性（65名白人）数据集中的所有患者在2-12周内每天接受2- 6mg利培酮治疗。发现两个snp与非裔美国人和白人患者在2-12周内对利培酮的反应有显著关联，并且在两个队列中具有一致的影响方向。代谢性谷氨酸受体（GRM3） SNP rs724226与阳性和阴性综合征量表（PANSS）总反应的变化相关。儿茶酚o -甲基转移酶（COMT） SNP rs165599与PANSS阴性评分的变化中度相关。与非裔美国人相比，白人患者中不良反应性GRM3和COMT等位基因的患病率更高，这可能对评估利培酮的种族特异性反应具有临床意义。The Pharmacogenomics Journal (2009) 9,311 -318；doi: 10.1038 / tpj.2009.24;2009年5月19日在线发布
Clinical trial data were evaluated for the association between 22 single-nucleotide polymorphisms (SNPs) and response in acutely ill patients diagnosed with schizophrenia, schizoaffective disorder or schizophreniform disorder, who were treated with oral risperidone. All patients in the exploratory (78 African Americans) and validation (65 whites) data sets received risperidone 2-6 mg per day over 2-12 weeks. Two SNPs were found to have significant associations with response to risperidone over 2-12 weeks in both African-American and white patients and had a consistent direction of effect in both cohorts. Metabotropic glutamate receptor (GRM3) SNP, rs724226, was associated with a change in the positive and negative syndrome scale (PANSS) total response. Catechol-O-methyltransferase (COMT) SNP, rs165599, was moderately associated with a change in the PANSS Negative score. The greater prevalence of poor-responder GRM3 and COMT alleles in white versus African-American patients might have a clinical significance in evaluating the ethnic-specific response to risperidone. The Pharmacogenomics Journal (2009) 9, 311-318; doi:10.1038/tpj.2009.24; published online 19 May 2009