Pathogenic Aspergillus species recovered from a hospital water system:: A 3-year prospective study
Pathogenic Aspergillus species recovered from a hospital water system:: A 3-year prospective study
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DOI：
10.1086/338958
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发表时间：
2002-03-15
影响因子：
11.8
通讯作者：
Walsh, TJ
中科院分区：
文献类型：
--
作者：
Anaissie, EJ;Stratton, SL;Walsh, TJ
医院曲霉病是一种危及免疫功能低下患者生命的感染，被认为主要是由空气中的曲霉菌引起的。一项为期3年的前瞻性研究的空气，环境表面，和水分配系统的医院，其中有已知的情况下，曲霉菌病进行，以确定其他可能的感染源。在医院供水系统中发现曲霉菌。在用水量最高的浴室（2.95 cfu/m（3））发现空气中曲霉菌繁殖体的浓度明显高于病房（0.78 cfu/m（3; P = .05）和走廊（0.61 cfu/m（3; P = .03）。从医院的水和空气中回收的曲霉属物种的等级顺序之间的相关性被发现。水箱中的水产生的菌落形成单位数高于市政用水。从曲霉病患者身上分离出的烟曲霉菌株与从患者房间淋浴墙分离出的菌株在基因型上相同。除空气外，医院供水系统也可能是医院曲霉病的来源。
Nosocomial aspergillosis, a life-threatening infection in immunocompromised patients, is thought to be caused primarily by Aspergillus organisms in the air. A 3-year prospective study of the air, environmental surfaces, and water distribution system of a hospital in which there were known cases of aspergillosis was conducted to determine other possible sources of infection. Aspergillus species were found in the hospital water system. Significantly higher concentrations of airborne aspergillus propagules were found in bathrooms, where water use was highest (2.95 colony-forming units [cfu]/m(3)) than in patient rooms (0.78 cfu/m(3;) P = .05) and in hallways (0.61 cfu/m(3); P = .03). A correlation was found between the rank orders of Aspergillus species recovered from hospital water and air. Water from tanks yielded higher counts of colony-forming units than did municipal water. An isolate of Aspergillus fumigatus recovered from a patient with aspergillosis was genotypically identical to an isolate recovered from the shower wall in the patient's room. In addition to the air, hospital water systems may be a source of nosocomial aspergillosis.