Lack of ingestive compensation to osmotic stimuli in chronic decerebrate rats.
Lack of ingestive compensation to osmotic stimuli in chronic decerebrate rats.
复制标题
慢性去大脑大鼠缺乏对渗透刺激的摄取代偿。
DOI：
10.1152/ajpregu.1981.240.1.r81
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Miselis,RR
中科院分区：
文献类型：
--
作者：
Grill,HJ;Miselis,RR
慢性去脑大鼠安装口腔瘘远程注射水或营养物质的能力进行了测试，以行为补偿脱水，增加他们的摄入量的水。去脑动物及其对照在各种挑战后以50微升等分试样通过口腔瘘管给予水以供摄入。大鼠从口中喷出水标志着饮水行为的终止。水的体积测量后1和24小时，胃内餐的普通饮食; 0.5，4，8，和24小时后皮下等渗或高渗NaCl注射;和1，4，8，和24小时后，胃内餐的普通或3% NaCl掺杂的饮食。与对照组不同，去脑剂未能增加细胞内脱水后摄入的水量，无论产生脱水的手段或允许响应的持续时间如何。然而，无论是控制和去大脑大鼠增加了他们的甜溶液（0.03 M蔗糖）的摄入，证明他们的能力，以应对和确认他们的能力，以弥补食物匮乏。去大脑大鼠脱水后的饮水量没有增加，这表明前脑中存在至少某些方面的调节回路，用于对水平衡进行行为控制。
Chronic decerebrate rats fitted with oral fistulas for remote injection of water or nutrient were tested for their capacity to behaviorally compensate for dehydration by increasing their ingestion of water. Decerebrates and their controls were given water for ingestion via the oral fistula in 50-microliter aliquots following various challenges. The rats' ejection of water from the mouth marked behavioral termination of the drinking. The volume of water was measured 1 and 24 h after an intragastric meal of regular diet; 0.5, 4, 8, and 24 h following subcutaneous isotonic or hypertonic NaCl injection; and 1, 4, 8, and 24 h following an intragastric meal of regular or 3% NaCl adulterated diet. Unlike controls, decerebrates failed to increase the amount of water ingested following intracellular dehydration regardless of the means of producing dehydration or the duration of time permitted for a response. However, both control and decerebrate rats increased their ingestion of a sweet solution (0.03 M sucrose) demonstrating their capacity to respond and confirming their ability to compensate for food deprivation. This lack of increased water intake in response to dehydration for decerebrate rats favors the existence of at least some aspects of the regulatory circuitry for this behavioral control of water balance to lie in the forebrain.