Orexin A activates locus coeruleus cell firing and increases arousal in the rat
Orexin A activates locus coeruleus cell firing and increases arousal in the rat
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DOI：
10.1073/pnas.96.19.10911
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发表时间：
1999-09-14
影响因子：
11.1
通讯作者：
Upton, N
中科院分区：
文献类型：
--
作者：
Hagan, JJ;Leslie, RA;Upton, N
食欲素神经肽在外侧下丘脑的定位关注于它们在摄入中的作用。然而，下丘脑外侧的促食神经元在大脑中广泛分布，因此促食素的生理作用可能是复杂的。本文采用组织定位、电生理和行为学相结合的方法研究了食欲素A对大鼠觉醒状态的调节作用。我们发现，受食欲能神经支配最密集的大脑区域是蓝斑，这是注意力状态的关键调节剂，在这里，食欲素a的应用增加了细胞内固有去肾上腺素能神经元的放电。食欲素A增加觉醒和运动活动，调节神经内分泌功能。数据表明，食欲素A在协调睡眠-觉醒周期中起着重要作用。
The localization of orexin neuropeptides in the lateral hypothalamus has focused interest on their role in ingestion. The orexigenic neurones in the lateral hypothalamus, however, project widely in the brain, and thus the physiological role of orexins is likely to be complex. Here we describe an investigation of the action of orexin A in modulating the arousal state of rats by using a combination of tissue localization and electrophysiological and behavioral techniques. We show that the brain region receiving the densest innervation from orexinergic nerves is the locus coeruleus, a key modulator of attentional state, where application of orexin A increases cell firing of intrinsic noradrenergic neurones. Orexin A increases arousal and locomotor activity and modulates neuroendocrine function. The data suggest that orexin A plays an Important role in orchestrating the sleep-wake cycle.